Results 51 to 60 of about 1,612 (126)

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Journal of Inflammation Research, 2017
Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of
Fonseca FCS, Orlando RM, Turchetti-Maia RMM, Francischi JN   +3 more
doaj  

Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain

Pharmacological Research
Chemotherapy-induced peripheral neuropathy (CIPN) significantly impacts patient’s quality of life and complicates cancer treatment. Neuroprotectin D1 (NPD1)/protectin D1 (PD1), derived from docosahexaenoic acid (DHA), exhibits analgesic actions in animal
Jing Xu, Sangsu Bang, Ouyang Chen, Yize Li, Aidan McGinnis, Qin Zhang, Ru-Rong Ji   +6 more
doaj   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

Allergy, EarlyView.
Jaime Bernaola, José Antonio Cañas, Álvaro Arranz‐Fragua, José Manuel Rodrigo‐Muñoz, Daniel Rodríguez‐González, Antonio Serrano‐Santiago, Gema Guillén‐Sánchez, Alma Martínez Fernández, Marcela Valverde‐Monge, Diana Betancor, Erwin Javier Pinillos‐Robles, Claudia Rodríguez‐Busto, María Jesús Rodríguez‐Nieto, Joaquín Sastre, Victoria del Pozo   +14 more
wiley   +1 more source

Exploring the nexus: Clinical and physiological correlation between cardiovascular disease and colorectal cancer

Experimental Physiology, Volume 111, Issue 4, Page 1708-1717, 1 April 2026.
Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir, Ali Murtada, Matti Jubouri, Wael Awad, Ian Williams, Damian M. Bailey   +5 more
wiley   +1 more source

Fish Oil Ameliorates Glycolipid Metabolism Disorders Induced by Long‐Term Potato Chip Diet Through Gut‐Liver Axis

Food Frontiers, Volume 7, Issue 1, January 2026.
Fried potato consumption is increasingly associated with metabolic disorders, yet preventive strategies remain poorly understood. In a 13‐week mouse model, long‐term potato chip intake induced significant glycolipid metabolic disturbances and tissue damage, which were ameliorated by fish oil supplementation through modulation of inflammation, hepatic ...
Xuzhi Wan, Xiaoran Song, Yingyu Huang, Qi Lu, Denghui Meng, Xiaohui Liu, Anli Wang, Pan Zhuang, Yilei Fan, Jingjing Jiao, Yu Zhang   +10 more
wiley   +1 more source

Trends and Prospects in Inflammation Resolution in Acute Lung Injury and Acute Respiratory Distress Syndrome: A Bibliometric Quantitative and Visualization Analysis

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are common and critical pulmonary conditions involving numerous inflammatory factors and oxidative stress responses. Inflammatory responses and oxidative stress are closely related to the development of ALI/ARDS and form an important theoretical basis for treatment and drug
Zixin Luo, Nan Huang, Kaihang Luo, Chenxi Wang, Jianhua Li, Kang Zou, Jasbir Arora (RSS)   +6 more
wiley   +1 more source

Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS

Journal of Lipid Research
Several oxylipins are regulators of inflammation. They are formed by enzymes such as lipoxygenases or cyclooxygenases, but also stereorandomly by autoxidation.
Nadja Kampschulte, Rebecca Kirchhoff, Ariane Löwen, Nils Helge Schebb   +3 more
doaj   +1 more source