Results 31 to 40 of about 1,612 (126)

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. [PDF]

PLoS ONE, 2015
Arachidonic acid (ARA) metabolites produced by cyclo-oxygenase and lipoxygenase are important mediators maintaining physiological renal function. However, the effects of exogenous ARA on kidney function in vivo remain unknown.
Masanori Katakura, Michio Hashimoto, Takayuki Inoue, Abdullah Al Mamun, Yoko Tanabe, Makoto Arita, Osamu Shido   +6 more
doaj   +1 more source

Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. [PDF]

J Nat Prod, 2014
Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators. PD1 (3) is a natural product that displays potent anti-inflammatory properties together with pro-resolving actions including ...
Tungen JE, Aursnes M, Vik A, Ramon S, Colas RA, Dalli J, Serhan CN, Hansen TV.   +7 more
europepmc   +6 more sources

Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. [PDF]

The Journal of Immunology, 2006
Abstract Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. The complete stereochemistry of protectin D1 (10,17S-docosatriene), namely, chirality of the carbon-10 alcohol and geometry of the conjugated triene, required for bioactivity ...
Charles N, Serhan, Katherine, Gotlinger, Song, Hong, Yan, Lu, Jeffrey, Siegelman, Tamara, Baer, Rong, Yang, Sean P, Colgan, Nicos A, Petasis   +8 more
openaire   +3 more sources

Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy

Nutrients, 2023
Background: Pregnancy is a physiological state during which inflammation occurs. This complex biological response is necessary for the implantation process as well as delivery. In turn, its suppression during gestation favors the normal course of the pregnancy. Therefore, the presence of pro-resolving mediators, EPA and DHA derivatives, The aim of this
Małgorzata Szczuko, Natalia Szwec-Nadworna, Joanna Palma, Małgorzata Tomasik, Maciej Ziętek   +4 more
openaire   +2 more sources

Protectin D1 alleviates cardiac ischemia-reperfusion injury in rats by up-regulating GPR37/JNK/PPAR-γ signaling pathway in cardiac macrophages

Di-san junyi daxue xuebao, 2019
Objective To investigate the mechanism by which protectin D1 (PD1) alleviates cardiac ischemia-reperfusion (IR) injury via GPR37/JNK/PPAR-γ signaling pathway.
ZENG Yalin, ZHOU Qin, XIONG Qingsong, CHEN Yunqing   +3 more
doaj   +1 more source

A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic-Associated Steatotic Liver Disease. [PDF]

FASEB J
The pro‐resolving lipid mediator PDX, and a novel synthetic analogue AN‐48, were orally administered (50 ng/g) daily to hamsters fed an obesity‐inducing diet. AN‐48 prevented hepatic triglyceride accretion and reduced the expression of fatty acid synthase (FASN), responsible for de novo lipogenesis.
Desmarais F, Maltais R, Sancéau JY, Marcotte B, Guèvremont G, Trottier J, Mitchell PL, Barbier O, Poirier D, Marette A.   +9 more
europepmc   +2 more sources

Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model

Molecules, 2014
The omega-3 polyunsaturated fatty acids (ω-3 PUFAs) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA) protect against diabetic nephropathy by inhibiting inflammation.
Masanori Katakura, Michio Hashimoto, Takayuki Inoue, Abdullah Al Mamun, Yoko Tanabe, Ryo Iwamoto, Makoto Arita, Satoru Tsuchikura, Osamu Shido   +8 more
doaj   +1 more source

Toll‐like receptor 7 stimulates production of specialized pro‐resolving lipid mediators and promotes resolution of airway inflammation

EMBO Molecular Medicine, 2013
Although specialized pro‐resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive.
Ourania Koltsida, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini‐Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N. Serhan, Evangelos Andreakos   +8 more
doaj   +1 more source

Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury

Frontiers in Immunology, 2013
Inflammation, in conjunction with leukocytes, plays a key role in most acute kidney injury (AKI). Non-resolving renal inflammation leads to fibrosis and chronic renal failure.
Song eHong, Yan eLu
doaj   +1 more source

Plasma leukotriene B₄ decreases after bariatric-metabolic surgery in severe obesity: A prospective observational study. [PDF]

Diabetes Obes Metab
Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7608-7613, December 2025.
Nishikage S, Hirota Y, Nakagawa Y, Shinohara M, Hosokawa Y, Nakajima S, Yoshimura K, Yamamoto A, Takayoshi T, Kitahama S, Ogawa W.   +10 more
europepmc   +2 more sources