Results 21 to 30 of about 1,612 (126)

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. [PDF]

Ann Neurol, 2013
Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury‐induced mechanical allodynia and ongoing pain in mice.
Xu ZZ, Liu XJ, Berta T, Park CK, Lü N, Serhan CN, Ji RR.   +6 more
europepmc   +4 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. [PDF]

Brain, 2018
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of the disease (epileptogenesis). There are no treatments for preventing seizures or improving disease prognosis, including neurological comorbidities. The search of pathogenic mechanisms of epileptogenesis highlighted that neuroinflammatory cytokines [i.e.
Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J, Vezzani A.   +16 more
europepmc   +6 more sources

Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. [PDF]

Prostaglandins Leukot Essent Fatty Acids, 2010
Retinal pigment epithelial (RPE) cells, derived from the neuroectoderm, biosynthesize the novel lipid mediator neuroprotectin D1 (NPD1) from docosahexaenoic acid (DHA) in response to oxidative stress or to neurotrophins, and in turn, elicits cytoprotection.
Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, Bazan NG.   +9 more
europepmc   +4 more sources

Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury [PDF]

The Journal of Immunology, 2006
Abstract Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. We report that, in response to bilateral ischemia/reperfusion injury, mouse kidneys produce D series resolvins (RvDs) and PD1.
Jeremy S, Duffield, Song, Hong, Vishal S, Vaidya, Yan, Lu, Gabrielle, Fredman, Charles N, Serhan, Joseph V, Bonventre   +6 more
openaire   +2 more sources

Estimation of salivary protectin D1 in periodontitis patients with metabolic syndrome following non-surgical periodontal therapy. [PDF]

Clin Oral Investig
Abstract Objectives This study aims to assess periodontal and biochemical parameters and evaluate the salivary Protectin D1 levels in periodontitis patients with and without metabolic syndrome after non-surgical periodontal therapy.
Selvaraj T, Mahendra J, Ravi N, Dave PH, Bedi M, Rao SMR, Yadalam PK, Ardila CM.   +7 more
europepmc   +3 more sources

Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes

Journal of Lipid Research, 2021
A proposed beneficial impact of highly unsaturated “fish oil” fatty acids is their conversion by lipoxygenase (LOX) enzymes to specialized proresolving lipid mediators, including 12/15-LOX products from EPA and DHA.
Jing Jin, William E. Boeglin, Alan R. Brash   +2 more
doaj   +1 more source

Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain [PDF]

Journal of Medicinal Chemistry, 2019
Protectin D1 [neuroprotectin D1 (NPD1), PD1] has been proposed to play a key role in the resolution of inflammation. Aside from its ω-monohydroxylated metabolite, little has been reported on its metabolic fate. Upon NPD1 incubation in HepG2 cells, liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed the formation of two main metabolites ...
Balas, Laurence, Risé, Patrizia, Gandrath, Dayaker, Rovati, Gianenrico, Bolego, Chiara, Stellari, Fabio, Trenti, Annalisa, Buccellati, Carola, Durand, Thierry, Sala, Angelo   +9 more
openaire   +4 more sources

2204 Characterizing specialized pro-resolving lipid mediators and synthesis pathways in veterans with peripheral artery disease

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease.
Joel Ramirez, Greg J. Zahner, Sukaynah A. Khetani, Kimberly A. Spaulding, Nancy K. Hills, S. Marlene Grenon   +5 more
doaj   +1 more source

Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis

iScience, 2020
Summary: Clostridium butyricum MIYAIRI 588 (CBM 588) is a probiotic bacterium that has previously been used to prevent antibiotic-associated diarrhea. However, the underlying mechanism by which CBM 588 protects the gut epithelial barrier remains unclear.
Mao Hagihara, Yasutoshi Kuroki, Tadashi Ariyoshi, Seiya Higashi, Kazuo Fukuda, Rieko Yamashita, Asami Matsumoto, Takeshi Mori, Kaoru Mimura, Naoko Yamaguchi, Shoshiro Okada, Tsunemasa Nonogaki, Tadashi Ogawa, Kenta Iwasaki, Susumu Tomono, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Yuka Yamagishi, Motomichi Takahashi, Hiroshige Mikamo   +20 more
doaj   +1 more source