Results 11 to 20 of about 1,612 (126)

Correction to "Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones". [PDF]

Oxid Med Cell Longev
Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
europepmc   +3 more sources

Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones. [PDF]

Oxid Med Cell Longev, 2022
Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cell (TEC) inflammatory and oxidative injury. This study is aimed at exploring potential therapeutic lipid components in kidney stones because lipids are involved in the development of several diseases and indicate the risk of kidney stones.
Wang B, Wei J, Huangfu Q, Gao F, Qin L, Zhong J, Wen J, Ye Z, Yang X, Liu H.   +9 more
europepmc   +4 more sources

Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. [PDF]

Org Biomol Chem, 2018
The first synthetic analog of protectin D1 with potent pro-resolving and anti-inflammatory properties is reported.
Tungen JE, Aursnes M, Ramon S, Colas RA, Serhan CN, Olberg DE, Nuruddin S, Willoch F, Hansen TV.   +8 more
europepmc   +4 more sources

A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution. [PDF]

Biochem Pharmacol, 2022
The production of specialized pro-resolving mediators (SPMs) during the resolution phase in the inflammatory milieu is key to orchestrating the resolution of the acute inflammatory response. 17-epi-neuroprotectin D1/17-epi-protectin D1 (17-epi-NPD1/17-epi-PD1: 10R,17R-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) is an SPM of the protectin ...
Hamidzadeh K, Westcott J, Wourms N, Shay AE, Panigrahy A, Martin MJ, Nshimiyimana R, Serhan CN.   +7 more
europepmc   +3 more sources

Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. [PDF]

Org Biomol Chem, 2014
A convergent stereoselective synthesis of the potent anti-inflammatory, proresolving and neuroprotective lipid mediator protectin D1 (2) has been achieved in 15% yield over eight steps. The key features were a stereocontrolled Evans-aldol reaction with Nagao's chiral auxiliary and a highly selective Lindlar reduction of internal alkyne 23, allowing the
Aursnes M, Tungen JE, Vik A, Dalli J, Hansen TV.   +4 more
europepmc   +4 more sources

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. [PDF]

J Immunol, 2007
Abstract Protectins are newly identified natural chemical mediators that counter leukocyte activation to promote resolution of inflammation. In this study, we provide the first evidence for protectin D1 (PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) formation from docosahexaenoic acid in human asthma in vivo and ...
Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN.   +8 more
europepmc   +6 more sources

Omega-3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution. [PDF]

Protein Sci
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Pérez-Sánchez Á, Garcia-Viloca M, González-Lafont À, Lluch JM.   +3 more
europepmc   +2 more sources

Resolvin E1 and protectin D1 activate inflammation-resolution programmes. [PDF]

Nature, 2007
Resolution of acute inflammation is an active process essential for appropriate host responses, tissue protection and the return to homeostasis. During resolution, specific omega-3 polyunsaturated fatty-acid-derived mediators are generated within resolving exudates, including resolvin E1 (RvE1) and protectin D1 (PD1).
Schwab JM, Chiang N, Arita M, Serhan CN.
europepmc   +4 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Pro-resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates. [PDF]

Br J Pharmacol, 2020
Background and PurposeSpecialized pro‐resolving mediators (SPMs) are a family of lipids controlling the resolution of inflammation and playing a role in many processes including organ protection and tissue repair. While SPMs are potent bioactive molecules in vivo, their role in epimorphic regeneration of organs in vertebrates has not been tested. Using
Nguyen-Chi M, Luz-Crawford P, Balas L, Sipka T, Contreras-López R, Barthelaix A, Lutfalla G, Durand T, Jorgensen C, Djouad F.   +9 more
europepmc   +4 more sources