Results 81 to 90 of about 393 (118)
MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E2. [PDF]
Stem Cell Res TherBermejo-Álvarez I +6 more
europepmc +1 more source
Catalysts, 2022 In the human body, docosahexaenoic acid (DHA) contained in fish oil is converted to trace amounts of specialized pro-resolving mediators (SPMs) as the principal bioactive metabolites for their pharmacological effects. Protectin Dx (PDX), an SPM, is an important medicinal compound with biological activities such as modulation of endogenous antioxidant ...
Kyung-Chul Shin +2 more
exaly +2 more sources
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Biochimie, 2014
There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non-cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects.
Thierry Durand +2 more
exaly +5 more sources
There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non-cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects.
Thierry Durand +2 more
exaly +5 more sources
Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX
The Journal of Organic Chemistry, 2018The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10 S,17 S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and C-17 were derived from readily available ( S)-1,2,4-butanetriol and ( R)-glycidol, respectively ...
Jean-Yves Sancéau +3 more
openaire +2 more sources
The Journal of Organic Chemistry, 2023
We report a gram-scale total synthesis of protectin DX (PDX) following a convergent synthetic route (24 steps) from l-malic acid. This novel synthetic strategy is based on the assembly of three main building blocks using a Sonogashira coupling reaction (blocks A and B) and Wittig olefination (block C) to provide the 22-carbon backbone of PDX.
René Maltais +3 more
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We report a gram-scale total synthesis of protectin DX (PDX) following a convergent synthetic route (24 steps) from l-malic acid. This novel synthetic strategy is based on the assembly of three main building blocks using a Sonogashira coupling reaction (blocks A and B) and Wittig olefination (block C) to provide the 22-carbon backbone of PDX.
René Maltais +3 more
openaire +2 more sources
International Immunopharmacology, 2020 Protectin DX (PDX) has been reported to have extensive anti-inflammatory effects. However, it is unknown whether PDX acts as an anti-inflammatory agent in the context of osteoarthritis (OA). This study aimed to evaluate the anti-inflammatory activity of PDX in vitro and in vivo in a model of OA.
Lunhao Bai, Xinyuan Feng
exaly +3 more sources
Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress
Cellular Signalling, 2017Several studies have shown that protectins, which are ω-3 fatty acid-derived proresolution mediators, may improve insulin resistance. Recently, protectin DX (PDX) was documented to attenuate insulin resistance by stimulating IL-6 expression in skeletal muscle, thereby regulating hepatic gluconeogenesis.
Tae Woo Jung +3 more
openaire +3 more sources
Immunologic Research, 2020
Previous reports have demonstrated that the newly identified lipid mediator protectin DX (PDX) could effectively attenuate multiple organ injuries in sepsis. The aim of our study was to clarify whether PDX could improve acute lung injury (ALI) induced by sepsis and elucidate the relevant potential mechanism.
Haifa Xia +10 more
openaire +2 more sources
Previous reports have demonstrated that the newly identified lipid mediator protectin DX (PDX) could effectively attenuate multiple organ injuries in sepsis. The aim of our study was to clarify whether PDX could improve acute lung injury (ALI) induced by sepsis and elucidate the relevant potential mechanism.
Haifa Xia +10 more
openaire +2 more sources
The FASEB Journal, 2021
Abstract Diabetic nephropathy (DN) remains the major cause of end‐stage renal disease (ESRD). We used high‐fat/high‐sucrose (HFHS)‐fed LDLr ‐/‐ /ApoB 100/100 mice with transgenic overexpression of IGFII in pancreatic β‐cells (LRKOB100 ...
Laís R. Perazza +9 more
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Abstract Diabetic nephropathy (DN) remains the major cause of end‐stage renal disease (ESRD). We used high‐fat/high‐sucrose (HFHS)‐fed LDLr ‐/‐ /ApoB 100/100 mice with transgenic overexpression of IGFII in pancreatic β‐cells (LRKOB100 ...
Laís R. Perazza +9 more
openaire +3 more sources
A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses
Journal of Medical VirologyAbstractAntiviral therapy based on neuraminidase (oseltamivir) or polymerase (baloxavir marboxil) inhibitors plays an important role in the management of influenza infections. However, the emergence of drug resistance and the uncontrolled inflammatory response are major limitations in the treatment of severe influenza disease.
Nicolas, Fortin +8 more
openaire +2 more sources