Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The context of REDD+ in the Lao People's Democratic Republic: drivers, agents and institutions [PDF]
, 2013 This report explores the drivers (both direct and indirect) of deforestation and forest degradation and discusses the political, economic and social opportunities and constraints that will influence the design and implementation of REDD+ in Laos.
Castella, Jean-Christophe +6 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing
IEEE AccessMicrogrid protection and ground fault management are critical aspects of modern power distribution systems, especially with the increasing integration of Distributed Generators (DGs) such as renewable energy sources.
Zahra Ghanem +7 more
doaj +1 more source
Optimal Coordination of Automatic Line Switches for Distribution Systems
Energies, 2012 For the Taiwan Power Company (Taipower), the margins of coordination times between the lateral circuit breakers (LCB) of underground 4-way automatic line switches and the protection equipment of high voltage customers are often too small. This could lead
Jyh-Cherng Gu, Ming-Ta Yang
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Protection costs, transaction costs,and economic theory [PDF]
Contractual reductionism takes market exchange as the ubiquitous form of economic organization throughout history. Transactions costs are accordingly regarded as the costs of running any economic system in general.
Vahabi, Mehrdad
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Mobile satellite services: International co-ordination, co-operation and competition [PDF]
In the context of a discussion of international cooperation, coordination and competition regarding mobile satellite services, it is asserted that: there will be more than one civil mobile satellite service in the 1990's; competition between these ...
Lundberg, Olof
core +1 more source
Evaluating the impact of superconducting fault current limiters on distribution network protection schemes [PDF]
, 2011 Rising fault levels are becoming increasingly problematic in the UK distribution network, with large sections of the network operating near to its designed fault level capability.
Abdulhadi, Ibrahim +3 more
core