Results 61 to 70 of about 1,156,648 (267)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Features of the Synthesis of Performance Security Information in Computer Systems

Безопасность информационных технологий, 2011
Synthesis of a scorecard is a gradual process of composition, since the set of elements that reflect the original, systematized their condition, and, through a series of intermediates, linking them in a single bound to the structure ends with one element
V. K. Dzhogan, A. P. Kurylo, N. S. Shimon   +2 more
doaj  

METHODS FOR PROTECTING SPEECH INFORMATION [PDF]

Prikladnaya diskretnaya matematika, 2008
Summary: Telephone conversations are the major channel of information interaction. The requirements for maintenance of speech confidentiality and for protecting information having the speech nature are growing. In the paper some problems arising in connection with the speech information protection are considered, and some ways for solving them are ...
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Using a Cloud-Based Electronic Signature System for Organizing Electronic Voting

Цифровая трансформация
The article is devoted to the research on the issues of voter authentication in electronic voting systems and the creation of a description of a system model that is designed to organize electronic voting using a cloud signature system as a reliable ...
V. А. Herasimau, М. А. Kazlouski
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Risk Management as Element of Economic Security in Companies Working with Digital Technologies

Вестник Российского экономического университета имени Г. В. Плеханова
The article shows the essence of economic security and identifies its key elements, the general classification of threats to economic security is provided.
S. P. Burlankov, K. O. Semenov, E. V. Galaktionova, V. A. Komarov   +3 more
doaj   +1 more source