Results 91 to 100 of about 163,116 (296)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

The voracious appetites of public versus private property: a view of intellectual property and biodiversity from legal pluralism [PDF]

"This paper argues, from the perspective of legal pluralism, that both private and public properties are voracious. In recent western developments, they each expand by trying to 'eating the other up'.
Wiber, Melanie G.
core  

Legal protections for traditional cultural expressions: An exploratory review of literature

Information Research: An International Electronic Journal
Introduction. Traditional cultural expressions are obviously an area of concern for Indigenous People but also for cultural heritage institutions (i.e., archives, museums and libraries) and international organizations.
Siyao Cheng, Sara R. Benson, Melissa G. Ocepek   +2 more
doaj   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

The effects of scales, flows and filters on property rights and collective action in watershed management: [PDF]

Research and policy on property rights, collective action and watershed management requires good understanding of ecological and socio-political processes at different social-spatial scales.
Garrity, Dennis P., van Noordwijk, Meine, Swallow, Brent M.   +2 more
core  

Psychological Aspects of Intellectual Property Protection

, 2015
Intellectual property is a result of creative intellectual work. It is a reflection of humans personality and individuality. Creative and research activities form an important part of intellectual activities.
Mingaleva, Zhanna, Mirskikh, Irina
core   +1 more source

Intuitive intellectual property law: A nationally-representative test of the plagiarism fallacy.

PLoS ONE, 2017
Studies with convenience samples have suggested that the lay public's conception of intellectual property laws, including how the laws should regulate and why they should exist, are largely incommensurate with the actual intended purpose of intellectual ...
Anne A Fast, Kristina R Olson, Gregory N Mandel   +2 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Protecting traditional ethno-botanical knowledge in South Africa through the intellectual property regime

Traditional knowledge has been used, and is increasingly being used, in a wide range of industries for the development of new products. Increasing awareness of the economic value of biological diversity has resulted in industries seeking to exploit ...
Vink, Nick, Daya, Y.
core  

Investments in Pharmaceuticals Before and After TRIPS [PDF]

We examine the relationship between patent protection for pharmaceuticals and investment in development of new drugs. Patent protection has increased around the world as a consequence of the TRIPS Agreement, which specifies minimum levels of intellectual
Margaret Kyle, Anita McGahan
core