Results 81 to 90 of about 163,116 (296)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

THE MODERN INSURANCE MARKET

Pravo, 2016
A man and his community have long been endangered by various perils threatening to destroy or harm them, jeopardize their life, health or property, questioning even their survival. Various forms of protection being applied had to continuously be improved
Bojana Ostojić, Nataša Lutovac, Marko Matić   +2 more
doaj  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

SISTEM REGISTRASI SEBAGAI ALTERNATIF DALAM MEMBERIKAN PERLINDUNGAN ATAS PENGETAHUAN TRADISIONAL (STUDI KASUS SENGKETA PENGETAHUAN TRADISIONAL ANTARA AMERIKA SERIKAT DAN INDIA) [PDF]

, 2008
Karya Ilmiah ini membahas mengenai sistem registrasi sebagai cara alternatif untuk memberikan perlindungan terhadap pengetahuan tradisional. Pemberian perlindungan bagi pengetahuan tradisional sangatlah penting untuk menghindarkan terjadinya ...
Prabandari, Adya Paramita
core  

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Piracy and counterfeiting: the freedom to copy vs. intellectual property rights.

, 1995
PhDSince 1980, many countries have passed new intellectual property laws, or revised their laws. The same period witnessed the birth of more trade associations which work to combat unauthorised copying.
Sodipo, Bankole Adekunle Akintoye
core  

LEGAL PROTECTION OF YEI PEOPLE'S KNOWLEDGE OF LOCAL MEDICINES AND MEDICINAL PLANTS FROM EXTINCTION

Masalah-Masalah Hukum
Food security investments have brought conflict between local indigenous communities and the government in South Papua. The research aims to encourage protection and recognition efforts from the state towards indigenous peoples' entities.
Sunardi Purwanda, Rudini Hasyim Rado, Diana Sri Susanti, Asriadi Zainuddin, Muh. Akbar Fhad Syahril   +4 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

DECISION SUPPORT SYSTEMS FOR ENVIRONMENT PEOPLE AND PROPERTY PROTECTION

, 1992
U ovom radu daje se prikaz naraslih potreba, sadašnjeg stanja i problema u sustavima za zaštitu okoliša, ljudi i vlasništva. Primjenom napredne informacijske tehnologije, temeljenom prvenstveno na umjetnoj inteligenciji, moguće će biti u znatnoj mjeri ...
Božidar Kliček, Kliček, Božidar
core  

Commercialization of Intellectual Property (IP) for Small and Medium Enterprisers (SMEs) in India

Lots of people in this modern era take the Intellectual property (IP) as a magical word and they think that the game can be understood only by the experts or the trained people.
Neeraj Parnami, Neeraj Parnami
core   +2 more sources