Results 51 to 60 of about 2,784,030 (294)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Modeling of spreading of the melted corium jet inside the pool of emergency heat removal during severe accidents at NPP [PDF]

Ядерна фізика та енергетика, 2012
Important nuclear power safety problem in touch with modeling of melted corium jet spreading inside the coolant pool is considered in the paper. It appears by development of the passive protection systems against se-vere accidents.
I. V. Kazachkov, O. V. Konoval
doaj  

Passive and active protection against disorders of the gut [PDF]

Veterinary Quarterly, 1998
The large surface area of mucosal surfaces, particularly of the gastrointestinal tract, is protected against microorganisms and environmental antigens by various innate factors (e.g., mucins, lactoferrin, and others) and specific antibodies which are of IgA, or in some species, IgG Isotypes.
J, Mestecky, M W, Russell
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Problem of corium melt coolability in passive protection systems against severe accidents in the containment [PDF]

Ядерна фізика та енергетика, 2018
Paper is devoted to the development of the mathematical model and analysis of the problem of corium melt interaction with low-temperature melting blocks in the passive protection systems against severe accidents at the NPP, which is of high importance ...
Ali Kalvand, I. V. Kazachkov
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

La modélisation au service de la conception des ouvrages de protection : étude du site avalancheux de Taconnaz [PDF]

Sciences, Eaux & Territoires, 2010
Optimiser la conception des ouvrages de protection contre les avalanches est une priorité pour la sécurité en montagne. À partir d'une étude réalisée dans le cadre des travaux de renforcement de l'ouvrage paravalanche du glacier de Taconnaz, construit ...
Mohamed Naaim, Thierry Faug, Florence Naaim-Bouvet et Nicolas Eckert
doaj   +2 more sources

Determinants of Cancer Early Detection Behaviors:Application of Protection Motivation Theory [PDF]

Health Promotion Perspectives, 2015
Background: Cancer is account for 13% of all deaths around the world and is the third cause of mortality in Iran. More than one third of these cases are pre-ventable and about 33% are curable with early detection.
Zohreh Rahaei, Fazlolah Ghofranipour, Mohammadali Morowatisharifabad, Eesa Mohammadi   +3 more
doaj   +1 more source

Passive Protection of Unarmoured Objects

Journal of Physics: Conference Series, 2021
Abstract This article presents problems related to passive composite protection of unarmoured objects (helicopters, vehicles, etc.). It is focused on building and testing the different add-on armours (panels) protecting unarmoured objects against small-arms armour piercing projectiles (kinetic energy - KE). It has been illustrated how to
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source