Results 121 to 130 of about 2,544,861 (297)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

[Protective and Detective Association, One Brown Horse Registration Form]

, 1885
An equine registration form.Recto: [imprinted] No. Dallas, Texas, 188. Protective and Detective Association. [handwritten in red] 14650. [descriptive text not transcribed]
Protective and Detective Association
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Kinship Quarterly: Strengthening Families [PDF]

, 2015
Quarterly newsletter related to the "Kinship Care by Child Protective Services (CPS)" program run by the Texas Department of Family and Protective Services containing departmental information and announcements, deadlines, and other information of ...
Texas. Department of Family and Protective Services.
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Correction to "Highly Oxidized Ecdysteroids from a Commercial Cyanotis arachnoidea Root Extract as Potent Blood-Brain Barrier Protective Agents". [PDF]

J Nat Prod, 2023
Tóth G, Santa-Maria AR, Herke I, Gáti T, Galvis-Montes D, Walter FR, Deli MA, Hunyadi A.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Towards Agents Participating in Realistic Multi-Unit Sealed-Bid Auctions

, 2008
When autonomous agents decide on their bidding strategies in real world auctions, they have a number of concerns that go beyond the models that are normally analyzed in traditional auction theory.
Jennings, Nick, Jennings, NR, Vetsikas, IA, Vetsikas, Ioannis   +3 more
core  

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Chi-square automatic interaction detection (CHAID) analysis of the use of safety goggles and face masks as personal protective equipment (PPE) to protect against occupational biohazards

Journal of Biosafety and Biosecurity
Background: This study represents the first Spanish investigation to rigorously evaluate compliance with the use of safety goggles and face masks as essential personal protective equipment (PPE) in companies with workplaces involving exposure to ...
Raúl Aguilar-Elena, Juán José Agún-González   +1 more
doaj   +1 more source

Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview. [PDF]

Molecules, 2022
Ibrahim SRM, Abdallah HM, El-Halawany AM, Mohamed GA, Alhaddad AA, Samman WA, Alqarni AA, Rizq AT, Ghazawi KF, El-Dine RS.   +9 more
europepmc   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source