Anthrax Vaccines in the 21st Century
VaccinesVaccination against Bacillus anthracis is the best preventive measure against the development of deadly anthrax disease in the event of exposure to anthrax either as a bioweapon or in its naturally occurring form.
Apostolos P. Georgopoulos, Lisa M. James
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Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax
mSphere, 2019 Inhalational anthrax caused by Bacillus anthracis, a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to ...
Jean-Nicolas Tournier +3 more
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DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin. [PDF]
Sci Rep, 2023 Becker L, Plückthun A.
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Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens. [PDF]
, 1987 We have employed the guinea pig model of L. pneumophila infection, which mimics Legionnaires' disease in humans both clinically and pathologically, to study humoral and cell-mediated immune responses to L.
Breiman, RF, Horwitz, MA
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Advanced Functional Materials, EarlyView.Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz +3 more
wiley +1 more source
Protective antigen domain 4 of Bacillus anthracis as a candidate for use as vaccine for anthrax
Annals of Agricultural and Environmental Medicine, 2019 Existing research for using the protective antigen (PA) of Bacillus anthracis as a vaccine component shows that protection against anthrax may be obtained using fragments of this protein. The aim of the research is to check whether the selected protein
Dorota Żakowska +5 more
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Solution Structures of Bacillus anthracis Protective Antigen Proteins Using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics. [PDF]
Toxins (Basel), 2021 Michelman-Ribeiro A +3 more
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Advanced Functional Materials, EarlyView.This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
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Receptor-enhanced immunogenicity of anthrax protective antigen is primarily mediated by capillary morphogenesis Protein-2. [PDF]
Vaccine, 2022 Verma A +6 more
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Preliminary assessment of various additives on the specific reactivity of anti- rHBsAg monoclonal antibodies [PDF]
, 2015 Background: Antibodies have a wide application in diagnosis and treatment. In order to maintain optimal stability of various functional parts of antibodies such as antigen binding sites, several approaches have been suggested.
Mohammadi, S. +3 more
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