Results 71 to 80 of about 1,176,869 (313)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Evaluating Risk and Protective Factors for Suicidality and Self-Harm in Australian Adolescents With Traditional Bullying and Cyberbullying Victimizations

, 2022
Purpose: To identify and compare important risk and protective factors associated with suicidality and self-harm among traditional bullying and cyberbullying victims aged 14-17-years in Australia. Design: Cross-sectional population-based study.
Islam, Md Irteja, Kabir, Enamul, Khanam, Rasheda, Yunus, Fakir Md   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cyberbullying: Definition, Prevalence, Effects, Risk and Protective Factors

Psikiyatride Güncel Yaklaşımlar
Cyberbullying is defined as intentional, repetitive, and harmful behaviors carried out using computers, cell phones, or other electronic devices. In recent years, there has been an increase in the rates of cyberbullying parallel to the rise in Internet ...
Burak Akdeniz, Aysun Doğan
doaj   +1 more source

Beyond osmolytes and transcription factors: drought tolerance in plants via protective proteins and aquaporins

, 2011
Mechanisms of drought tolerance have been studied by numerous groups, and a broad range of molecules have been identified to play important roles. A noteworthy response of stressed plants is the accumulation of novel protective proteins, including heat ...
M. T. Iqbal, S. S. Hussain, M. Amjad, M. A. Arif   +3 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Identifying risk factors and protective factors for venous leg ulcer recurrence using a theoretical approach : a longitudinal study

, 2015
Background\ud \ud The high recurrence rate of chronic venous leg ulcers has a significant impact on an individual’s quality of life and healthcare costs. \ud \ud Objectives\ud \ud This study aimed to identify risk and protective factors for recurrence of
Edwards, Helen E., Wu, Min-Lin, Edwards, Helen E, Finlayson, Kathleen   +3 more
core   +1 more source

The role of external protective factors on young entrepreneurs' entrepreneurial resilience: an explorative study [PDF]

, 2017
To receive support is crucial among youth in order for them to achieve success in life as it could hinder social exclusion, especially for at-risk young people. Empowering the potentials of at-risk youth through the support of external protective factors
Nurliza Khalid, Abdullah, Haslinda, Suandi, Turiman, Manap, Jamiah, Idris, Fazilah, Jamiah Manap, Haslinda Abdullah, Khalid, Nurliza, Fazilah Idris, Kamaruddin, Siti Hajar, Siti Hajar Kamaruddin, Turiman Suandi   +11 more
core   +1 more source