Results 141 to 150 of about 1,245,002 (304)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

U.S. trade policy towards developing countries [PDF]

The United States has often been criticized for protectionist measures taken against developing country products. Yet, average agricultural protection has reemained practically nil in the U.S. over time, while rising in the European Common Market (E.C.M)
Balassa, Bela
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Методичні підходи до розвитку і вдосконалення системи економічної безпеки підприємства [PDF]

, 2013
Запропоновано спосіб оцінки ефективності захисних заходів, алгоритм якого включає експертну оцінку небезпек існуючих загроз і ступеня протидії їм використовуваних захисних заходів.
Хаустова, Ірина Євгенівна
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The impact of protective measures against COVID-19 on the wellbeing of residents in nursing homes and their relatives: a rapid review. [PDF]

BMC Geriatr, 2023
Schneider P, Abt M, Cohen C, Marmier N, Ortoleva Bucher C.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Awareness of Tehran residents of seven warning signs of cancer, and application of protective measures against cancer

Basic & Clinical Cancer Research, 2013
The present study aimed to determine awareness of Tehran residents of seven warning signs of cancer, and application of protective measures against cancer. 2500 residents of Tehran were selected through systematic cluster random sampling. Data collection
Mitra Zolfaghari, Zohreh Parsa-yekta, Fatemeh Behramnezhad, Anooshirvan Kazemnejad, Zahra Monjamed   +4 more
doaj  

Coronavirus (COVID-19): implementing protective measures in education and childcare settings [PDF]

, 2020

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