Results 131 to 140 of about 1,245,002 (304)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Family foster care: a protective alternative for children and adolescents / Acolhimento familiar: uma alternativa de proteção para crianças e adolescentes

open access: yesPsicologia: Reflexão e Crítica, 2009
Foster care of children and adolescents who have had their rights violated is being discussed both in the scientific literature and in agencies involved in the development of public policies.
Nina Rosa do Amaral Costa   +1 more
doaj  

National security: A propositional study to develop resilience indicators as an aid to personnel vetting [PDF]

open access: yes, 2010
Within the National Security domain there is a convergence of security responsibility across the national security agencies, law enforcement and private security sectors. The sensitivity of this environment requires individuals operating in the domain to
Brooks, David   +5 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Personal protective measures and settings on the risk of SARS-COV-2 community transmission: a case-control study. [PDF]

open access: yesFront Public Health, 2023
Huguet-Torres A   +5 more
europepmc   +1 more source

The efficiency cost of protective measures in climate policy

open access: yes, 2016
Despite recent achievements towards a global climate agreement, climate action to reduce greenhouse gas emissions remains quite heterogeneous across countries.
Arto, Iñaki   +3 more
core  

Parents Anonymous Outcome Evaluation: Promising Findings for Child Maltreatment Reduction [PDF]

open access: yes, 2008
Parents Anonymous(R) mutual support groups for parents are aimed at strengthening families and reducing child maltreatment. NCCD performed a national evaluation to assess whether parent participation in Parents Anonymous(R) was associated with change in ...

core  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Effectiveness of Protective Measures and Rules in Reducing the Incidence of Injuries in Combat Sports: A Scoping Review. [PDF]

open access: yesJ Funct Morphol Kinesiol, 2023
Štyriak R   +4 more
europepmc   +1 more source

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