Results 111 to 120 of about 1,245,002 (304)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The role of peers and parents in predicting alcohol consumption among Chilean youth [PDF]
, 2012 This study estimated marginal associations of parent- and peer-related measures to examine the different patterns of lifetime ever-use and frequency of alcohol consumption among adolescents in Santiago, Chile (N=918).
Delva, J.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Acta Agriculturae Slovenica, 2008 Among free living animals in Slovenia, wild boar (Sus scrofa) damages agricultural land by rooting and primarily by directly feeding on open fields. In some areas of Slovenia this large wildlife animal causes more than 50% of all estimated damage to ...
Matej VIDRIH, Stanislav TRDAN
doaj +1 more source
The ecomics of ecosystems and biodiversity: scoping the scale [PDF]
, 2008 The G8 decided in March 2007 to initiate a “Review on the economics of biodiversity loss”, in the so called Potsdam Initiative: 'In a global study we will initiate the process of analysing the global economic benefit of biological diversity, the costs of
Balmford, A. +6 more
core +1 more source
Protecting the neighborhood: Extreme measures [PDF]
Proceedings of the National Academy of Sciences, 1998 In the unending wars of organism vs. organism, the growth of bacteriophage and the defenses raised by bacteria were among the first recognized and continue to provide new variations and insights on ways to defend oneself. A paper in this issue of the Proceedings demonstrates that prokaryotes, like eukaryotes, have chosen proteolytic self-destruction as
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Functional preservation of vascular smooth muscle tissue [PDF]
The ionic and cellular feedback relationships operating to effect the vascular decompensatory modifications were examined to reveal procedures for implementing protective measures guarding against vascular collapse when returning from a weightless ...
Alexander, W. C. +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source