Results 101 to 110 of about 1,245,002 (304)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

THE ROLE OF BELARUS NATIONAL COMMISSION ON RADIATION PROTECTION IN THE MINIMIZATION OF CONSEQUENCES OF THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT

open access: yesРадиационная гигиена, 2016
The Belarus National Commission on Radiation Protection was established in 1991, based on the former Byelorussian Soviet Socialist Republic Supreme Council Resolution.
A. N. Stozharov   +2 more
doaj   +1 more source

The precautionary approach and the management of the European eel (Anguilla anguilla) – critical remarks [PDF]

open access: yes, 2007
Recruitment and commercial catches of European eel have been in decline since the late 1970s. So far, the reasons are not well understood. A range of potential natural and anthropogenic reasons have been discussed, but the relative importance of the ...
Wysujack, Klaus
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Mental health of residents of radioactively contaminated territories of the Chelyabinsk region in the late period after the resettlement

open access: yesРадиационная гигиена
In case of radiation accidents, one of the radical protective measures is the evacuation of residents from contaminated areas. Its purpose is to reduce the possible radiation effect to the population. At the same time, evacuation itself becomes a serious
E. Yu. Burtovaia
doaj   +1 more source

Sport, children's rights and violence prevention: A source book on global issues and local programmes [PDF]

open access: yes, 2012
Copyright @ Brunel University, 2012In line with the Convention on the Rights of the Child (CRC), UNICEF has been a strong advocate of children’s right to leisure and play.
Brackenridge, CH, Kay, T, Rhind, D
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Measuring protection: a cautionary tale [PDF]

open access: yesJournal of Development Economics, 1997
Abstract This paper comments on a theoretically based index of protection recently developed by Anderson and Neary. The index must be calculated within the context of a specific CGE model; Anderson and Neary propose a generic model, and have found that the index is robust to changes in the elasticities embedded within that model.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Toxin-neutralizing antibodies protect against Clostridium perfringens challenge in an intestinal loop model for bovine enterotoxaemia [PDF]

open access: yes, 2015
Bovine enterotoxaemia caused by Clostridium perfringens type A most often presents as a sudden death syndrome with necro-hemorrhagic small intestinal lesions in suckling calves and veal calves (Muylaert et al., 2010).
Deprez, Piet   +9 more
core  

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