Results 51 to 60 of about 518,808 (262)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

The Application of Waste Silica Cyclone Powder for the Protective Coating of Steel Billets [PDF]

open access: yesMetalurgija, 2007
The role of a protective coating is to diminish the steel surface scaling during the reheating for hot rolling. The protective coating consists of several components, and the effect of the coating is based on the formation of the modification of Al2O3 ...
Torkar, M.   +3 more
doaj  

Colloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SAR-CoV-2. [PDF]

open access: yesNano Sel, 2022
Khorsand Kheirabad A   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Effect of Plasma Electrolytic Oxidation Process as a Pretreatment on Corrosion Resistance of Polymeric Coatings Applied on Mg Alloy

open access: yesJournal of Advanced Materials in Engineering, 2020
In this study, Plasma Electrolytic Oxidation (PEO) at three frequencies of 500, 1000 and 3000 Hz was applied on Mg surface and the effect of PEO surface preparation on protective behavior of three types of epoxy, fusion bond epoxy (FBE) and polyurethane ...
M. Toorani Farani
doaj  

Corrosion Inhibition Effect of Carbon Steel in Sea Water by L-Arginine-Zn2+ System

open access: yesInternational Journal of Chemical Engineering, 2014
The inhibition efficiency of L-Arginine-Zn2+ system in controlling corrosion of carbon steel in sea water has been evaluated by the weight-loss method. The formulation consisting of 250 ppm of L-Arginine and 25 ppm of Zn2+ has 91% IE.
S. Gowri, J. Sathiyabama, S. Rajendran
doaj   +1 more source

Effect of Deformation-Induced Martensite on Protective Performance of Passive Film on 304 Stainless Steel

open access: yesInternational Journal of Electrochemical Science, 2018
The relationships among the characteristics and electrochemical properties of passive films on the surfaces of 304 stainless steel specimens with different deformation-induced martensite content were examined using X-ray diffraction spectroscopy (XRD ...
Shanlin He, Daming Jiang, Zhaoyuan Sun
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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