Results 61 to 70 of about 518,808 (262)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Optimization design of stress relief coalbed methane surface well in a high-gas mine

Frontiers in Earth Science
Coalbed methane drainage through surface wells has become increasingly important in high-gas mines. Surface wells are prone to different types of deformations and failures owing to mining-induced effects.
Junhui Fu, Guangcai Wen, Bichuan Zhang, Haitao Sun, Rifu Li, Jiaqi Liu   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Friction parameter surface treated concrete with a remedy against dryness [PDF]

Строительство уникальных зданий и сооружений, 2014
The article devoted to developing techniques for measuring the parameters of road friction and airfield pavements in order to study the influence of external factors on the slip resistance of concrete surfaces treated with care products ...
Yuri Germanovich Barabanshchicov, Vitalij Anatolievich Gatiullin, Muhanna Ala   +2 more
doaj  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Bioinspired hierarchical coating with superhydrophobic bacterial-repellency and photothermal sterilization for reusable infection-resistant personal protective equipment

Nano Research
High-performance personal protective equipment (PPE) is indispensable for the prevention of infectious diseases. However, the protective effect of PPE is significantly weakened due to pathogens surviving on the fabric surface.
Ronghua Wang, Yuemiao Mao, Ruyue Duan, Yan Zhang, Xia Liu, Shuxun Cui   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Calculation of the hydraulic characteristics of the protective coating used in trenchless technologies for the construction and renovation of pipelines to extend their service life

MATEC Web of Conferences, 2017
The lifetime of the pipeline, which undergoes trenchless repair by pulling and then fixing various types of internal protective coatings inside, is determined by the strength characteristics of the two-layer structure “old pipeline + internal protective ...
Orlov Vladimir, Zotkin Sergey, Dezhina Irina, Zotkina Irina   +3 more
doaj   +1 more source

Effectiveness of Protective Action of Coatings from Moisture Sorption into Surface Layer of Sand Moulds

Archives of Metallurgy and Materials, 2016
The results of investigations of the sorption process of surface layers of sand moulds covered by zirconium and zirconium - graphite alcohol coatings are presented in the paper. Investigations comprised two kinds of sand grains (silica sand and reclaimed
Kaźnica N., Zych J.
doaj   +1 more source