Results 41 to 50 of about 116,059 (245)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

Pesquisa Veterinária Brasileira
: Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with
Douglas S. Caragelasco, Márcia M. Kogika, Cínthia R. Martorelli, Khadine K. Kanayama, Denise M.N. Simões   +4 more
doaj   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Índice proteinúria/creatininúria em gestantes com hipertensão arterial

Clinical and Biomedical Research, 2022
OBJETIVO: Estabelecer o nível da relação proteína/ creatinina urinária com melhor predição para o diagnóstico de proteinúria significativa em gestantes com hipertensão arterial sistêmica.
José Geraldo L. Ramos, Elvino G. Barros, Sérgio Martins-Costa   +2 more
doaj  

Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission. [PDF]

PLoS ONE, 2017
Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes.We retrospectively enrolled consecutive patients ...
Koji Inagaki, Yoshinari Yasuda, Masahiko Ando, Ahmad Baseer Kaihan, Asaka Hachiya, Takaya Ozeki, Manabu Hishida, Takahiro Imaizumi, Takayuki Katsuno, Sawako Kato, Naotake Tsuboi, Shoichi Maruyama   +11 more
doaj   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Impact of Renin‐Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen, Ryo Seishima, Masayoshi Monno, Satoru Morita, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa   +6 more
wiley   +1 more source

Protein-to-creatinine urinary in the early diagnosis of renal injury in canine pyometra

Pesquisa Veterinária Brasileira
: Kidney disease that affects bitches with pyometra may lead patients to develop chronic renal failure even after pyometra treatment. Therefore, several studies have sought to clarify the gaps in the understanding of the pathogenesis of renal injury in ...
Marcos C. Sant’Anna, Guilherme F. Martins, Karina K.M.C. Flaiban, Luiz G.C. Trautwein, Maria I.M. Martins   +4 more
doaj   +1 more source

Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWhether changes in proteinuria are associated with incident stroke in the general population is unclear. This study aimed to investigate the association between changes in proteinuria and incident stroke and its subtypes. Methods and ResultsThe
Anxin Wang, Xiaoxue Liu, Zhaoping Su, Shuohua Chen, Nan Zhang, Shouling Wu, Yongjun Wang, Yilong Wang   +7 more
doaj   +1 more source