Results 91 to 100 of about 9,193,993 (329)

Deducing topology of protein-protein interaction networks from experimentally measured sub-networks. [PDF]

, 2008
BackgroundProtein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein ...
Han, Zhangang, Maclellan, W Robb, Qu, Zhilin, Vondriska, Thomas M, Weiss, James N, Yang, Ling   +5 more
core   +3 more sources

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

Nature Communications, 2016
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery ...
Nambin Yim, S. Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, Mohammed R. Shaker, Woong Sun, Ji-Ho Park, Daesoo Kim, Won Do Heo, Chulhee Choi   +12 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Modularity detection in protein-protein interaction networks

BMC Research Notes, 2011
Background Many recent studies have investigated modularity in biological networks, and its role in functional and structural characterization of constituent biomolecules.
Narayanan Tejaswini, Gersten Merril, Subramaniam Shankar, Grama Ananth   +3 more
doaj   +1 more source

An automated method for finding molecular complexes in large protein interaction networks

BMC Bioinformatics, 2003
BackgroundRecent advances in proteomics technologies such as two-hybrid, phage display and mass spectrometry have enabled us to create a detailed map of biomolecular interaction networks. Initial mapping efforts have already produced a wealth of data. As
Gary D. Bader, Christopher W. V. Hogue
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Phospho‐tyrosine dependent protein–protein interaction network

Molecular Systems Biology, 2015
Post‐translational protein modifications, such as tyrosine phosphorylation, regulate protein–protein interactions (PPIs) critical for signal processing and cellular phenotypes.
Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl   +6 more
doaj   +1 more source

RocSampler: regularizing overlapping protein complexes in protein-protein interaction networks

BMC Bioinformatics, 2017
Background In recent years, protein-protein interaction (PPI) networks have been well recognized as important resources to elucidate various biological processes and cellular mechanisms.
Osamu Maruyama, Yuki Kuwahara
doaj   +1 more source

A systematic survey of centrality measures for protein-protein interaction networks

bioRxiv, 2017
BackgroundNumerous centrality measures have been introduced to identify “central” nodes in large networks. The availability of a wide range of measures for ranking influential nodes leaves the user to decide which measure may best suit the analysis of a ...
Minoo Ashtiani, Ali Salehzadeh-Yazdi, Zahra Razaghi-Moghadam, H. Hennig, O. Wolkenhauer, M. Mirzaie, Mohieddin Jafari   +6 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source