FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope. [PDF]
J Biol ChemKleanthous C.
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Quantum-augmented graph differential geometry enhances accuracy in protein-protein interaction prediction. [PDF]
Sci RepKarthick V +4 more
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Splitpea: a Python package for protein-protein interaction network rewiring analysis due to alternative splicing. [PDF]
BioinformaticsZhong J, Cantu A, Dannenfelser R, Yao V.
europepmc +1 more source
Exploratory Study of Virulence Factors and Protein-Protein Interaction Networks in Major Oral Pathogens. [PDF]
Contemp Clin DentMurmu M, Singh R, Barage S, Kumar AWS.
europepmc +1 more source
Revealing drug targets for sepsis: An association study integrating Mendelian randomization, eQTL, pQTL, and protein-protein interaction networks. [PDF]
Medicine (Baltimore)Lu E +5 more
europepmc +1 more source
Molecular tweezer-peptide conjugates disrupt the protein-protein interaction between survivin and histone H3 essential in mitosis. [PDF]
Beilstein J Org ChemGsell C +7 more
europepmc +1 more source
Genetic Polymorphisms Associated with Lithium Response in Bipolar Disorder: An Integrative Review and In Silico Protein-Protein Interaction Analysis. [PDF]
Pharmaceuticals (Basel)Ejiohuo O, Szczepankiewicz A.
europepmc +1 more source