Results 221 to 230 of about 2,914,082 (253)

From Concepts to Inhibitors: A Blueprint for Targeting Protein-Protein Interactions. [PDF]

Chem Rev
Hong SH, Nguyen T, Ongkingco JF, Nazzaro A, Arora PS.   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

TIE-UP-SIN: a novel method for enhanced identification of protein-protein interactions. [PDF]

Front Microbiol
Schedlowski M, Michalik S, Hoffmüller T, Harms M, Steil L, Surmann K, Hentschker C, Salazar MG, Völker U, Reder A.   +9 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Single-Molecule Array (Simoa) Technology as a Highly Sensitive Screening Tool for Protein-Protein Interactions. [PDF]

ACS Sens
Lim Y, Norman M, Chen C, Cho IT, Walt DR, Cho G, Golden JA.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long-read sequencing to detect full-length protein-protein interactions. [PDF]

Sci Rep
Schaefer-Ramadan S, Guan Y, Ahmed AA, Aleksic J, Elmagarmid KA, Syed LF, Mohamoud YA, Malek JA.   +7 more
europepmc   +1 more source

PLM-interact: extending protein language models to predict protein-protein interactions. [PDF]

Nat Commun
Liu D, Young F, Lamb KD, Claudio Quiros A, Pancheva A, Miller CJ, Macdonald C, Robertson DL, Yuan K.   +8 more
europepmc   +1 more source

Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria. [PDF]

Int J Mol Sci
Maj P, Trylska J.
europepmc   +1 more source

Structural basis of pseudoGTPase-mediated protein-protein interactions. [PDF]

Structure
Wang B, Yang R, Wan C, Tian Y, Wu J, Adewole TS, Roy S, Li S, Shen J, Yin Q.   +9 more
europepmc   +1 more source