Results 71 to 80 of about 7,140 (156)

Desenvolvimento de metodologia analítica por cromatografia líquida de alta eficiência e eletroforese capilar para análise de citrulina em matrizes biológicas: Ana Claudia Vieira; orientador, Flavio Henrique Reginatto. [PDF]

, 2014
A intensa busca por novos biomarcadores de doenças com intuito de melhorar o diagnóstico e acompanhar a evolução da doença tem feito os pesquisadores reavaliar compostos antes ignorados, como a citrulina.
Vieira, Ana Claudia
core  

A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease

, 2015
This work was supported by the Ministry of Education, Youth and Sports CZ (no. LD14009, no. SV/FVZ201201, no. SVV260062), COST CM1103, MH CZ - DRO (UHHK, 00179906), The Alzheimer’s Society, The Barcopel Foundation and the MSD Scottish Life Sciences fund ...
Gunn-Moore, Frank J, Musilek, Kamil, Benek, Ondrej, Kuca, Kamil, Aitken, Laura, Hroch, Lukas   +5 more
core   +1 more source

Preliminary study on the role of peptidyl arginine deiminase 4 in the regulation of maxillofacial development

Objective To investigate the effect of peptidyl arginine deiminase 4(PAD4) on the differentiation of mesenchymal stem cells isolated from oral bones(OMSC) and craniomaxillofacial development.
YAN Xingzhi, CAI Xinyu, CHEN Simai, FANG Weiwen, LEI Fan, CAO Dan, ZHANG Yang
core   +1 more source

Strict Aerobic Lifestyle and Anaerobic Survival of Bacteria: Inseparable Twins?

Molecular Microbiology, Volume 125, Issue 6, Page 546-551, June 2026.
ABSTRACT For many decades the existence of strict aerobic bacteria was part of every textbook. However, considering habitats like soils or surfaces, many of these microorganisms are exposed to drastic changes in oxygen tension. A simple rain shower can change oxygen diffusion rates by a factor of 10.000.
Meina Neumann‐Schaal, José Manuel Borrero‐de Acuña, Dieter Jahn   +2 more
wiley   +1 more source

Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach

Rheumatoid Arthritis (RA) is the second most common type of arthritis with symptoms first appearing in patients between 40 and 60 years of age. The number of older persons is projected to double to 1.5 billion in 2050, globally.
Leonardo B. Federico, Ruan S. Bastos, Cleydson B.R. Santos, Jorddy N. Cruz, Renato A. da Costa, Suraj N. Mali, Rai C. Silva, José A.H.M. Bittencourt, Carlos H.T.P. da Silva, Cleison C. Lobato, Njogu M. Kimani   +10 more
core   +1 more source

Screening, design, synthesis and bioactivity of inhibitors against Protein Arginine Deiminase type IV [PDF]

, 2015
Protein Arginine Deiminase IV (PAD4) is a new target for rheumatoid arthritis (RA) therapeutic. It catalyses the citrullination process in human body that produces citrullinated protein which is believed to be the root cause of RA.
Teo, Chian Ying
core  

New autoantigens in rheumatoid arthritis (RA): screening 8268 protein arrays with sera from patients with RA

, 2009
International audienceOBJECTIVE:To identify new IgG autoantibodies in sera from patients with rheumatoid arthritis (RA).METHODS:We tested serum samples from 19 patients with RA with given human leukocyte antigen (HLA)-DR genotypes, from 7 patients with ...
Lambert, N., Roudier, J, Auger, Isabelle, Balandraud, N, Martin, M., Rak, J   +5 more
core   +1 more source

Envolvimento de canais de potássio na inibição da proliferação de células de mastocitoma pelo óxido nítrico [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Curso de Pós-Graduação em FarmacologiaVários efeitos do [óxido nítrico] devem-se à ativação de [guanilato ciclase] ou alteração do funcionamento de [canais de
Costa, Renata Souza Agostinho
core  

Peptidyl arginine deiminase type 2 (PAD‐2) and PAD‐4 but not PAD‐1, PAD‐3, and PAD‐6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation

, 2007
International audienceAbstract Objective Autoantibodies to citrullinated proteins (ACPAs) are specific for rheumatoid arthritis (RA) and probably are involved in its pathophysiology.
Méchin, Marie‐claire, Yamada, Michiyuki, Foulquier, Céline, Nachat, Rachida, Sebbag, Mireille, Chapuy-Regaud, Sabine, Al Badine, Roula, Serre, Guy, Clavel, Cyril, Takahara, Hidenari, Simon, Michel, Vincent, Christian, Guerrin, Marina   +12 more
core   +1 more source

Proteomic investigation of the group B streptococcus

The Group B Streptococcus (GBS) is a Gram-positive opportunistic pathogen which is a leading cause of neonatal disease globally. In 2000-2001, the general incidence of neonatal GBS infection was 0.72 per 1000 live births in U.K. and the mortality rate is
Yang, Qian
core