Results 81 to 90 of about 7,140 (156)
, 2018 Citrullination is a post-translational modification (PTM) that serves many normal physiological functions. Studies have shown that this PTM-along with expression of the catalyzing enzymes, peptidyl arginine deiminases (PADs)-are increased in autoimmune ...
Beranova-Giorgianni, Sarka +5 more
core +1 more source
, 2016 BACKGROUND: The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. Lung inflammation with resultant protein citrullination may trigger anti-citrullinated protein antibodies, inflammation, and arthritis ...
Shim, Daeun +8 more
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Abstract 1102: Regulation of protein citrullination through p53/PADI4 network in DNA damage response
, 2010 Upon wide range of cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes related to apoptosis, cell cycle arrest, and DNA repair. However its involvement in post-translational
Yusuke Nakamura +2 more
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Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes
, 2018 Background: Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications. Methods: We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes
Schiano, Concetta +8 more
core +1 more source
, 2013 *Alleles shown as major allele/minor allele ...
Yoshiaki Toyama (12534) +7 more
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Inibição do edema de pata de camundongo induzido pela injeção de doadores de óxido nítrico: envolvimento de guanilato ciclase solúvel e de canais de potássio [PDF]
, 2002 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O [óxido nítrico] é uma molécula com inúmeras ações em vários sistemas.
Fernandes, Daniel
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Functional Characterization of Calcium Binding Sites 3, 4, 5 in Peptidylarginine Deiminase type 4
, 2014 胜肽精胺酸去亞胺酶 (Peptidylarginine deiminase)是一種後轉譯修飾的酵素，在有鈣離子的情況下可以將蛋白質上的精胺酸 (arginine)轉變為瓜胺酸 (citrulline)，胜肽精胺酸去亞胺酶總共有五種異構型 (isoforms)，其中第四型胜肽精胺酸去亞胺酶近年來被認為是偵測類風濕性關節炎的重要因子。到目前為止，只有第四型胜肽精胺酸去亞胺酶的結構被結晶出來，從蛋白結構中可以知道第四型胜肽精胺酸去亞胺酶有五個鈣離子的結合位，分別為將這些鈣離子簡稱為Ca1、Ca2、Ca3 ...
Chang, Chia-Wei, 張家維
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Recombinant arginine deiminase (rADI) and its synergism with chemotherapeutic drugs
, 2013 化學藥物治療目前對於癌症治療是很重要的方式。目前臨床上使用的化療藥物可分為細胞週期專一性以及非專一性，治療方式常採用合併藥物治療。而併用針對不同細胞週期的化療藥物，可能會改變原本藥物的效果，如協同 (synergism)、加成 (additive effect) 或拮抗作用 (antagonism)。此外，使用不同的給藥順序也會可能影響到化療藥物併用的結果。 精胺酸去亞胺酶 (arginine deiminase; ADI) 已經在臨床試驗中被證實用於治療肝癌、黑色素癌；這類的癌細胞被稱為精胺酸缺乏型 (
孫厚鈞, Sun, Hou-Chun
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, 2014 胜肽精胺酸 (Peptidylarginine deiminase) 是一種後轉譯修飾酵素，在有鈣離子的情況下可以將蛋白質上的精胺酸 (arginine)轉變為瓜胺酸 (citrulline)，胜肽精胺酸總共有五種異構型 (isoforms) ，其中，第四型胜肽精胺酸近年來被認為是研究類風濕性關節炎的重要對象。第四型胜肽精胺酸和鈣離子結合前後的結構，都已經被結晶分析出來。從蛋白結構中可以知道，第四型胜肽精胺酸有五個鈣離子的結合位，分別將這些鈣離子簡稱為 Ca1、Ca2、Ca3、Ca4、Ca5 ...
蔡一成, Tsai, I-Chen
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Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
, 2010 Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in ...
Lin Wang, Xiaotian Chang, Guangying Yuan, Yan Zhao, Pengcheng Wang
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