Results 31 to 40 of about 918 (139)

From a novel pathogenic SAMD9L variant to cohort‐wide insights: Whole‐genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity

British Journal of Haematology, EarlyView.
Summary Germline gain‐of‐function variants in sterile alpha motif domain–containing 9‐like (SAMD9L), located on chromosome 7q, cause a multisystem disorder characterized by bone marrow failure, immunodeficiency and variable neurological involvement. Disease evolution is frequently shaped by somatic genetic rescue (SGR), most commonly through monosomy 7,
Hadjer Dellal, Roman Klifa, Lise Larcher, Marie Passet, Tristan Celse, Laetitia Gouas, Maud Tusseau, AURAGEN Consortium, Alexis Praga, Virginie Bernard, Mathieu Fusaro   +10 more
wiley   +1 more source

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source

Codocytosis in the Dog: 345 Cases (2020–2022)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Introduction Codocytes, or target cells, are a morphologic variation of erythrocytes characterized by increased membrane surface area relative to volume. In dogs, codocytosis is frequently noted on blood smear evaluation, but its clinical significance remains poorly understood. Objectives To characterize the clinical conditions associated with
Sarena M. Krojanker, Maria Jaramillo, Brad D. Cingolani, Floyd L. Williams Jr., Priscila B. S. Serpa, Andrew D. Woolcock   +5 more
wiley   +1 more source

Faecal Microbiota Transplantation Reduces Lesion Severity and Medication Use in Canine Atopic Dermatitis: A Randomised, Placebo‐Controlled, Double‐Blinded Clinical Trial

Veterinary Dermatology, EarlyView.
Background: Faecal microbiota transplantation (FMT) is an established therapy for gastrointestinal disease, yet its role in canine atopic dermatitis (cAD) remains unclear. Hypothesis/Objectives: We hypothesised that adjunctive FMT improves clinical severity and reduces symptomatic medication use in dogs with cAD.
Vera Felten, Erin Asley West, Franco Martini, Claude Favrot, Stefan Unterer, Jan Suchodolski, Michael Scharl, Harald Renz, Nina Maria Fischer, Ana Rostaher   +9 more
wiley   +1 more source

When a Bulbar Ulcer Hides a Darker Reality: The Unusual Diagnosis of a Portal Cavernoma in a 69‐Year‐Old Adult

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT A portal cavernoma is a network formed by localized dilation of the hepatic portal system. This study aims to describe a case of portal cavernoma in a 69‐year‐old adult presenting with gastrointestinal hemorrhage. This is a 69‐year‐old patient with no particular medical history admitted for hematemesis associated with diffuse abdominal pain ...
Martin Wendlassida Nacanabo, André Arthur Taryètba Seghda, Aimé Arsène Yaméogo, Ella Hatoula Lengani, Adolphe Benjamin Zingué Ouattara, Aminata Guiarra, Yannick Laurent Tchenadoyo Bayala, Abdoul Nassir Porgo, Abdoul Aziz, Abdoul Djalilou Traoré, Anna Tall/Thiam, Georges Christian Millogo, Valentin Nobila Yaméogo, André Koudnoaga Samadoulougou   +13 more
wiley   +1 more source

Magnetic Resonance Imaging Features of Intravascular Osteosarcoma Affecting the Ventral Internal Vertebral Venous Plexus Causing Cervical Myelopathy in a Dog

Veterinary Radiology &Ultrasound, Volume 67, Issue 4, July 2026.
ABSTRACT A 10.5‐year‐old male castrated Standard Poodle was referred for the evaluation of chronic C6–T2 myelopathy. MRI revealed a severe asymmetric enlargement of the ventral internal vertebral venous plexus, intervertebral/vertebral veins, and possibly the C6 basivertebral vein, with secondary mild spinal cord compression.
Robert Wise, Rachel Durrwachter, Nathan Fanzone, Wilfried Mai   +3 more
wiley   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Association of Protein-losing Enteropathy and Cryoglobulinaemia

Scandinavian Journal of Gastroenterology, 2003
We describe a case of protein-losing enteropathy in association with cryoglobulinaemia. No underlying disorder could be definitively diagnosed, but several clinical and laboratory findings suggested an immune mediated or autoimmune disorder. We propose that the mechanism of the protein-losing enteropathy in our case was immune complex formation ...
Samarkos, M, Vaiopoulos, G, Andreopoulos, A, Chatzidimitriou, D, Alevizou-Terzaki, V, Aessopos, A   +5 more
openaire   +3 more sources

Mosunetuzumab Successfully Treated Rituximab‐Refractory Lymphoma‐Associated Protein‐Losing Enteropathy With Concomitant Immune Thrombocytopenia in Follicular Lymphoma: A Case Report

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Protein‐losing enteropathy (PLE) is a rare but potentially severe complication of malignant lymphoma characterized by excessive gastrointestinal loss of plasma proteins, leading to hypoalbuminemia, edema, and serous effusions. We report a case of follicular lymphoma complicated by severe PLE and concomitant immune thrombocytopenia (ITP ...
Takashi Matsunaga, Naohi Sahara, Mai Mizusawa, Yukiko Miura, Seiichiro Kobayashi, Tomoki Fujii, Nobuhiro Oono   +6 more
wiley   +1 more source

Expanding Phenotype of GINS1 Deficiency: A Case Report and Review of the Literature

Clinical Genetics, Volume 109, Issue 6, Page 1076-1080, June 2026.
The authors present a novel case and review of individuals with GINS1 deficiency, causing severe growth restriction and combined immunodeficiency. Only the ninth case of this ultrarare disorder, it highlights the role of these variants in disease, glaucoma as a feature, and the possibility of immunodeficiency without infections in affected individuals.
Michael P. Mackley, Rae Brager, Hannah Geddie, Vicky Breakey, Rebecca Hough, Dimitrios J. Stavropoulos, Vanda McNiven   +6 more
wiley   +1 more source