Results 51 to 60 of about 3,492,819 (130)

Results From a Phase 2, Open‐Label Study Evaluating the Safety, Tolerability, and Effect on Ataxia of GLM101 in Three Adult Patients With PMM2‐CDG

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase 2 congenital disorder of glycosylation (PMM2‐CDG) is a rare, autosomal recessive disease caused by PMM2 deficiency, which impairs conversion of mannose‐6‐phosphate into mannose‐1‐phosphate (M1P) and disrupts N‐linked glycosylation.
Mercedes Serrano, Florencia Epifani, Rose Marino, Peter McWilliams   +3 more
wiley   +1 more source

An extensively hydrolysed protein-based extruded diet in the treatment of dogs with chronic enteropathy and at least one previous diet-trial failure: a pilot uncontrolled open-label study

BMC Veterinary Research
Background Canine chronic enteropathies (CE) are a group of disorders defined by persistent or recurrent clinical signs of gastrointestinal disease without a primary neoplastic, metabolic, parasitic, or other infectious cause.
Valérie Freiche, Olivier Dossin, Amélie Leclerc, Isabelle Mougeot, Jeremy Laxalde, Olivier Roy, Vincent Biourge, Alexander J. German   +7 more
doaj   +1 more source

Non‐Invasive Assessment of Endothelial Dysfunction and Arterial Stiffness in Fontan Circulation

European Journal of Clinical Investigation, Volume 56, Issue 9, September 2026.
The Fontan procedure is the definitive treatment for complex congenital heart disease, creating a circulation without a subpulmonary ventricle. This altered hemodynamic state negatively affects endothelial function, contributing to progressive organ dysfunction and long‐term morbidity.
Amalia Baroutidou, Eleni Pagkopoulou, Vasileios Kamperidis, Antonios Ziakas, Theodoros Dimitroulas, George Giannakoulas   +5 more
wiley   +1 more source

A script to highlight hydrophobicity and charge on protein surfaces [PDF]

, 2015
The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo, Stefan G. D. Rüdiger, Dominique Hagemans, Cellular Protein Chemistry, Ianthe A. E. M. van Belzen, Ianthe A.E.M. van Belzen, van Belzen, Ianthe A E M, Sub Cellular Protein Chemistry, Morán Luengo, Tania, Rüdiger, Stefan G D, Tania Morán Luengo, Dominique eHagemans, Hagemans, Dominique   +12 more
core   +2 more sources

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, Volume 67, Issue 9, Page 798-809, September 2026.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source

‘Losing Work, Losing Purpose’: Representations of Musicians' Mental Health in the Time of Covid-19

, 2022
Driven by a growing academic and professional interest in the subject over recent years (Eynde et.al, 2016; Vaag et.al, 2016; Berg et.al, 2018; Shorter et.al, 2018; Gross and Musgrave, 2020), discussions concerning the mental health and emotional ...
Musgrave, G.
core   +1 more source

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Protein-losing gastroenteropathy: Concepts derived from lymphangiography [PDF]

, 1965
Lymphangiograms in 2 patients with protein-losing gastroenteropathy showed abnormalities of both abdominal and lower-extremity lymphatics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44359/1/10620_2005_Article_BF02237631 ...
French, Arthur B., H. Marvin Pollard, Joseph J. Bookstein, Pollard, H. Marvin, Bookstein, Joseph J., Arthur B. French   +5 more
core   +1 more source

Two-dimensional grayscale ultrasound and spectral Doppler waveform evaluation of dogs with chronic enteropathies

, 2007
Sonography is an important diagnostic tool to examine the gastrointestinal tract of dogs with chronic diarrhea. Two-dimensional grayscale ultrasound parameters to assess for various enteropathies primarily focus on wall thickness and layering.
Gaschen, Lorrie, Kircher, Patrick, Kircher, Patrick R; https://orcid.org/   +2 more
core   +1 more source