Results 121 to 130 of about 8,952,616 (310)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses [PDF]

, 2004
Zöllner FG. Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses. Bielefeld (Germany): Bielefeld University; 2004.Für das Verständnis von biologischen Funktionen können Proteindockingverfahren ...
Frank G. Zöllner, Zöllner, Frank Gerrit   +1 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Protein-Protein Interactions [PDF]

Revista Brasileira de Ciências Farmacêuticas, 2004
Pedrazzi G, Stagljar I
openaire   +5 more sources

Modulators of Protein–Protein Interactions [PDF]

Chemical Reviews, 2014
Milroy, L., Grossmann, T., Hennig, S., Brunsveld, L., Ottmann, C.   +4 more
openaire   +4 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Development of a Split Esterase for Protein-Protein Interaction Dependent Small Molecule Activation [PDF]

, 2019
Split reporters based on fluorescent proteins and luciferases have emerged as valuable tools for measuring interactions in biological systems. Relatedly, biosensors that transduce measured input signals into outputs that influence the host system are key
Alexander, Lippert, Jared C., Lewis, Bryan, Dickinson, Krysten A., Jones, Weiwei, An, Michael, Beck, Kaitlin, Kentala   +6 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Protein-protein interaction of pathogen protein CD630_32050 (putative nitroreductase) with PDB ID: 3GFA acquired from STRING database.

Protein-protein interaction of pathogen protein CD630_32050 (putative nitroreductase) with PDB ID: 3GFA acquired from STRING database.
Asifullah Khan (5901902), Abbas Ahmad (16517912), Yasir Ali (799969), Zhongjie Han (5793275), Sara Aiman (9090834), Muneeba Aslam (5901896), Jilong Zhang (2294710), Qurrat ul Ain Farooq (16698860), Chunhua Li (18618)   +8 more
core   +1 more source

Towards the prediction of protein interaction partners using physical docking

Molecular Systems Biology, 2011
Deciphering the whole network of protein interactions for a given proteome (‘interactome’) is the goal of many experimental and computational efforts in Systems Biology.
Mark Nicholas Wass, Gloria Fuentes, Carles Pons, Florencio Pazos, Alfonso Valencia   +4 more
doaj   +1 more source