Results 181 to 190 of about 8,552,186 (306)

Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures. [PDF]

Genome Biol
Tamandeh E, Kunwar K, Bigge J, Serohijos A, Schumacher J, Maj C, Dasmeh P.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Optimized Quantitative Bacterial Two-Hybrid (qB2H) for Protein-Protein Interaction Assessment. [PDF]

Comput Struct Biotechnol J
Guyot A, Maillard E, Ferreira-Pinto K, Plançon-Arnould L, Nadaradjane AA, Guérois R, Ochsenbein F, Martin L, Ramos OHP.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SPPIPred: Stacking-based ensemble learning model for identification of protein-protein interaction. [PDF]

PLoS One
Rahman MA, Ali MM, Shohidullah M, Ahmed K, Bui FM, Chen L, Moni MA, Moni MA.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Human protein-protein interaction prediction

BMC Bioinformatics, 2010
Scott Michelle S, McDowall Mark D, Barton Geoffrey J   +2 more
doaj   +1 more source

Multiplex mapping of protein-protein interaction interfaces. [PDF]

Proc Natl Acad Sci U S A
He J, Zou LN, Pareek V, Benkovic SJ.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The role of protein embeddings for protein-protein interaction prediction with graph neural networks. [PDF]

Brief Bioinform
Balbi L, Sousa RT, Cotovio P, Pesquita C.   +3 more
europepmc   +1 more source