Results 161 to 170 of about 336,318 (323)

Differential action of a protein tyrosine kinase inhibitor, genistein, on the positive inotropic effect of endothelin‐1 and norepinephrine in canine ventricular myocardium [PDF]

, 2005
Li Chu, Jianxin Zhang, Ikuo Norota, Masao Endoh   +3 more
openalex   +1 more source

Proof of concept of NX‐2127, a first‐in‐class Bruton's Tyrosine Kinase (BTK) dual‐targeted protein degrader with immunomodulatory activity, in patients with DLBCL [PDF]

, 2023
Alexey V. Danilov, Krish Patel, Weiyun Z. Ai, Michael Wang, Clare Sun, Philip O’Connor, A. Schwab, M. Tan, Adrian Wiestner   +8 more
openalex   +1 more source

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells

, 2018
Sumiyasuren Buyanravjikh, Sora Han, Sunyi Lee, Ae Lee Jeong, Hye In Ka, Ji Park, Ariundavaa Boldbaatar, Jong‐Seok Lim, Myeong‐Sok Lee, Young Yang   +9 more
openalex   +2 more sources

Protein Tyrosine Kinase [PDF]

, 2020
openaire   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

, 1993
Naoki Kobayashi, Takahiro Kono, Masatsugu Hatakeyama, Y Minami, Tamana Miyazaki, Roger M. Perlmutter, Tatsuya Taniguchi   +6 more
openalex   +2 more sources

Dok‐3 sequesters Grb2 and inhibits the Ras‐Erk pathway downstream of protein‐tyrosine kinases [PDF]

, 2006
Miyuki Honma, Osamu Higuchi, Masaki Shirakata, Tomoharu Yasuda, Hiroshi Shibuyà, Shun‐ichiro Iemura, Tohru Natsume, Yuji Yamanashi   +7 more
openalex   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, EarlyView.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source

Dynamic regulatory features of the protein tyrosine kinases. [PDF]

Biochem Soc Trans, 2019
Amatya N, Lin DY, Andreotti AH.
europepmc   +1 more source