Results 201 to 210 of about 184,784 (335)
Advanced Science, EarlyView.Hypothalamus sympathetic norepinephrine inhibits regeneration of articular cartilage. Mechanical loading on bone during animal activity elevates PGE2 skeletal interoception to promote an anabolic renewal of the superficial membrane by downregulation of norepinephrine for articular cartilage proper thickness and integrity.
Ziyi Wang +8 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Characterization of distinct tyrosine-specific protein kinases in B and T lymphocytes
, 1985 openalex +2 more sources
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
Advanced Science, EarlyView.This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv +6 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022 Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu +13 more
wiley +1 more source
The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases. [PDF]
, 1992 Tomáš Cinek, Václav Hořejšı́
openalex +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. [PDF]
, 1992 Sara Nakielny +3 more
openalex +1 more source