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Platelet Protein Tyrosine Kinases [PDF]

, 1997
The first protein tyrosine kinase (PTK) to be identified, detected by Hunter and Sefton in 1979, was the transforming protein of the Rous sarcoma virus (Hunter and Sefton 1980). This 60-kDa phosphoprotein is encoded by the viral src oncogene (v-src) and is denoted pp60 v-src .
E. A. Martinson, P. Presek
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Cytokine signaling through nonreceptor protein tyrosine kinases.

Science, 1995
Cytokines are a family of soluble mediators of cell-to-cell communication that includes interleukins, interferons, and colony-stimulating factors. The characteristic features of cytokines lie in their functional redundancy and pleiotropy.
T. Taniguchi
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6 Protein Tyrosine Kinase Inhibitors

1996
Publisher Summary This chapter describes the classification and structure of protein tyrosine kinases (PTKs), their mode of action, their cellular targets, and the processes in which they are involved. A vast amount of research has been carried out to try to identify the role of PTKs in the general functioning and development of normal mammalian ...
Kevin R. H. Solomons, Paul W. Groundwater, Jacqueline A. Drewe, Munawar Ali Munawar   +3 more
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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.

Science, 1993
A mouse phosphotyrosine phosphatase containing two Src homology 2 (SH2) domains, Syp, was identified. Syp bound to autophosphorylated epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors through its SH2 domains and was ...
G. Feng, C. Hui, T. Pawson
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Nuclear protein tyrosine kinases

Trends in Biochemical Sciences, 1994
Protein tyrosine phosphorylation plays an important role in the transduction of extracellular signals. The prototypical protein tyrosine kinases are localized at the plasma membrane and are coupled to receptors that bind extracellular factors. Thus, protein tyrosine phosphorylation was previously thought to occur only in the cytoplasm. However, several
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Protein—Tyrosine Kinases and Their Substrates [PDF]

, 1990
Protein phosphorylation, through its ability to increase or decrease the activity of proteins, plays a central role in cellular regulation. Most proteins known to be regulated by phosphorylation are substrates for both a protein kinase and a protein phosphatase.
David S. Middlemas, Tony Hunter, David P. Thompson, Kathleen L. Gould, Richard A. Lindberg, Jill Meisenhelder   +5 more
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The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.

Annual Review of Immunology, 1994
Engagement of the T cell antigen receptor (TCR) by peptide antigen bound to the major histocompatibility complex (MHC) molecules initiates a biochemical cascade involving protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases). Recent
Andrew C. Chan, D. Desai, Arthur Weiss
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Regulation of protein tyrosine kinases in platelets

Trends in Biochemical Sciences, 1994
Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated ...
Edwin A. Clark, Joan S. Brugge, Sanford J. Shattil   +2 more
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Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases.

International journal of peptide & protein research, 2009
Using a random combinatorial peptide library method [Wu, J., Ma, Q. N. & Lam, K. S. (1994) Biochemistry 33, 14825-14833] a novel peptide, YIYGSFK, was identified as a substrate for p60c-src protein tyrosine kinase. Mass spectrometric analysis showed that
K. Lam, J. Wu, Q. Lou
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Fertilization signalling and protein-tyrosine kinases

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000
Fertilization is initiated by species-specific gamete cell recognition, i.e. sperm-egg interaction, followed by a rapid and sustained activation of multiple cellular and biochemical events, collectively called 'egg activation', which is indispensable for successful formation of zygotic nucleus and later embryogenesis.
Ken-ichi Sato, Yasuo Fukami, Alexander A. Tokmakov   +2 more
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