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src-related protein tyrosine kinases
1989Tyrosine protein kinases (TPKs) catalyze the transfer of phosphate groups from nucleotide triphosphates to tyrosine residues on proteins and peptides. While phosphorylation of proteins on tyrosine residues is a well-known post-radiational event detected in different regulatory systems, only a small number of cellular proteins are known substrates for ...
Joseph B. Bolen, André Veillette
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In vitro substrate specificity of protein tyrosine kinases
Molecular and Cellular Biochemistry, 1993Synthetic peptides such as P60src autophosphorylation site peptides and angiotensin are indiscriminately phosphorylated by protein tyrosine kinases. The observation has led to the general belief that protein tyrosine kinases are highly promiscuous, displaying little in vitro site specificity.
Heung-Chin Cheng +2 more
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Structure and function of the protein tyrosine kinases
Progress in Growth Factor Research, 1990The protein tyrosine kinases (PTKs) are a large and structurally diverse family of enzymes. The conserved catalytic domain held in common by each member of this family is a self-contained 250-300 amino acid unit bearing sixteen highly conserved linear sequence elements, several of which have been shown to be important to the catalytic activity of this ...
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Butein, a Specific Protein Tyrosine Kinase Inhibitor
Biochemical and Biophysical Research Communications, 1998Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p60c-src (IC50 = 65 microM) in vitro.
Yang, E.-B. +3 more
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Src-Related Protein Tyrosine Kinases in Hematopoiesis
Blood, 1999T HE PROLIFERATION and differentiation of blood cell progenitors and precursors are tightly regulated by approximately a dozen different growth factors, which act primarily on hematopoietic cells.[1][1] In addition, growth factors that stimulate a wider variety of cell types, such as insulin ...
Steven M. Anderson, Seth J. Corey
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Proximal protein tyrosine kinases in immunoreceptor signaling
Current Opinion in Immunology, 2001Immunoreceptor engagement results in the sequential activation of several classes of protein tyrosine kinases, including the Src and Syk/Zap-70 families. Recent progress has been made in our understanding of the regulation and function of these molecules. First, it was revealed that membrane compartmentation of protein tyrosine kinases may be essential
Sylvain Latour, André Veillette
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[29] Inhibition of protein-tyrosine kinases by tyrphostins
1991Publisher Summary This chapter discusses the inhibition of protein-tyrosine kinases by tyrphostins. Many protein tyrosine kinases (PTKs) catalyze the phosphorylation of tyrosine residues on exogenous substrates and the autophosphorylation of tyrosine residues.
Aviv Gazit +4 more
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Protein Tyrosine Kinases in Human Brain and Gliomas
Journal of Neurochemistry, 1992Abstract: Tyrosine kinase activity was determined in neonatal and adult human brain, oligodendrogliomas, and astrocytomas. The astrocytomas were divided into low‐ (grade I and grade II) and high‐grade (grade III and grade IV) tumors. We measured the tyrosine kinase activity in the cytosolic and membrane fraction using poly(glutamic acid:tyrosine, 4:1)
Jessica H. W. Heijden +5 more
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The ErbB/HER family of protein-tyrosine kinases and cancer.
Pharmacological Research, 2014R. Roskoski
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Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells
Critical reviews in clinical laboratory sciences, 2014Elżbieta Gocek +2 more
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