Results 101 to 110 of about 15,507,347 (338)
Recruitment of proteins to modulate protein-protein interactions
Chemistry & Biology, 1999 The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand with its protein target has been reported recently. This approach represents a general method for modulating protein-protein interactions and may find many applications in both biology and medicine.
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
Nucleic Acids Res., 2014 Protein structure homology modelling has become a routine technique to generate 3D models for proteins when experimental structures are not available. Fully automated servers such as SWISS-MODEL with user-friendly web interfaces generate reliable models ...
M. Biasini +10 more
semanticscholar +1 more source
Scientific ReportsDNA double-strand breaks (DSBs) activate DNA damage responses (DDRs) in both mitotic and meiotic cells. A single-stranded DNA (ssDNA) binding protein, Replication protein-A (RPA) binds to the ssDNA formed at DSBs to activate ATR/Mec1 kinase for the ...
Arivarasan Sampathkumar +5 more
doaj +1 more source
Nature Communications, 2016 CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso +13 more
doaj +1 more source
ProDGe: investigating protein-protein interactions at the domain level [PDF]
, 2011 An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Adrian Schrö +5 more
core +2 more sources
Effects of Proteins on Protein Diffusion [PDF]
Journal of the American Chemical Society, 2010 Despite increased attention, little is known about how the crowded intracellular environment affects basic phenomena like protein diffusion. Here, we use NMR to quantify the rotational and translational diffusion of a 7.4-kDa test protein, chymotrypsin inhibitor 2 (CI2), in solutions of glycerol, synthetic polymers, proteins, and cell lysates.
Yaqiang Wang +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
UniProt: a hub for protein information
Nucleic Acids Res., 2014 UniProt is an important collection of protein sequences and their annotations, which has doubled in size to 80 million sequences during the past year.
The Uniprot Consortium
semanticscholar +1 more source
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
Cell Communication and Signaling, 2022 Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of voltage-gated ion channels, but a full picture of ...
Martyna Sochacka +6 more
doaj +1 more source