Results 211 to 220 of about 11,920,429 (358)
Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim +11 morewiley +1 more sourceGenomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text
Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton +19 morewiley +1 more sourceMitochondrial protein import [PDF]
, 1989 Ades, Ades, Adrian, Ainger, Allison, Alt, Aquila, Aquila, Arakawa, Arends, Argan, Argan, Baker, Banroques, Basile, Beckmann, Bedwell, Behra, Bellion, Beltzer, Beltzer, Berkhout, Bhasker, Bhat, Blobel, Borst, Bouillaud, Boutry, Brandriss, Braun, Burns, Böhni, Böhni, Cerletti, Chatton, Chen, Chen, Chen, Chen, Chen, Cheng, Chien, Chien, Chirico, Chu, Conboy, Conboy, Coruzzi, Craig, Dahl, Daum, Daum, De Haan, De Jong, De Lange, De Lange, Deshaies, Dickerson, Dieckmann, Dieckmann, Douglas, Duffaud, Dumont, Eilers, Eilers, Eilers, Ellis, Ellis, Emr, Epand, Evans, Farrell, Farrell, Faye, Firgaira, Fisher, Flügge, Foury, Fox, Freeman, Freitag, Fujiki, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gasser, Gay, Gearing, Geller, Gillespie, Gilmore, Gilmore, Grant, Grossmann, Guiard, Hackenbrock, Hallemayer, Hallermayer, Hallewell, Hampsey, Hansen, Harmey, Harmey, Harmey, Harmey, Harnisch, Hartl, Hartl, Hartl, Hartl, Hase, Hase, Hase, Hatalova, Hauska, Hawlitschek, Hay, Heinrich, Hemmingsen, Hennig, Hennig, Hennig, Henning, Hensgen, Ho, Ho, Horwich, Horwich, Horwich, Horwich, Horwich, Horwich, Hunter, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Imanaka, Ito, Jaussi, Jaussi, Joh, Just, Kanazawa, Kaput, Kellems, Kellems, Kellens, Keng, Kirwin, Kleene, Koerner, Koerner, Koike, Kolansky, Kolarov, Korb, Kraus, Kraus, Kraus, Kraus, Krebs, Kruse, Kryzwicki, Kun, Labouesse, Lazarow, Lederer, Lennart-Nilsson, Lewin, Lewin, Lindquist, Lingelbach, Lomax, Lubben, Lustig, Lustig, Maarse, Maarse, Maccecchini, Maccecchini, Macino, Maher, Marres, Marzuki, Matsubara, Matsuura, McAda, McGraw, McIntyre, Meyer, Meyer, Meyer, Michel, Mihara, Mihara, Mihara, Mihara, Miura, Miura, Mori, Mori, Morita, Morohashi, Morohashi, Morohashi, Mueckler, Mueckler, Mueckler, Myers, Myers, Müller, Müller, Nagata, Nakagawa, Nargang, Natsoulis, Nelson, Nelson, Ness, Neupert, Neupert, Nguyen, Nguyen, Nguyen, Nguyen, Nicholson, Nicholson, Nicholson, Nicholson, Nishikimi, Nyunoya, Oda, Oda, Ohashi, Ohba, Ohba, Ohta, Ohta, Okamura, Okamura, Ono, Ono, Ono, Ono, Ou, Ou, Oudshoorn, Pain, Pain, Pape, Pape, Park, Patterson, Pelham, Perara, Pfaller, Pfaller, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pillar, Pollock, Pratje, Pratje, Randall, Randall, Raymond, Reid, Reid, Richter, Ricquier, Ridley, Rietveld, Riezman, Riezman, Riezman, Robinson, Roise, Roise, Rothblatt, Rothman, Runswick, Rödel, Römisch, Sabatini, Sachs, Sadler, Saraste, Schatz, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmeizer, Schmidt, Schmidt, Schmidt, Schmidt, Schmidt, Schneller, Schwaiger, Schägger, Sebald, Shore, Sidhu, Sierra, Simmaco, Skerjank, Smagula, Stellwagen, Stuart, Suissa, Suissa, Surguchov, Suske, Sztul, Söllner, Takeda, Takeda, Takiguchi, Tamm, Taniuchi, Teintze, Tropschug, Tzagoloff, Tzagoloff, Ueda, Urban-Grimal, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Steeg, Vasarotti, Vasarotti, Veloso, Velours, Verner, Vestweber, Viebrock, Von Heijne, Walter, Walter, Walter, Watanabe, Waters, Watts, Weiss, Werner, Wickner, Wiech, Wielburski, Wierenga, Witte, Wold, Woodrow, Wright, Wright, Wu, Yaffe, Yaffe, Yamane, Yoshida, Yoshida, Young, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski, Zwizinski +395 morecore +1 more sourceThe subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany +9 morewiley +1 more sourceA nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun +13 morewiley +1 more sourceTherapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim +18 morewiley +1 more sourceUnraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández +12 morewiley +1 more source
