Results 51 to 60 of about 10,756,110 (307)

ProDGe: investigating protein-protein interactions at the domain level [PDF]

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Adrian Schrö, Andreas Drä, Andreas Zell, Clemens Wrzodek, Finja Bü, Florian Mittag   +5 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Protein-Protein Docking with F2Dock 2.0 and GB-Rerank [PDF]

, 2013
Rezaul Chowdhury is with UT Austin; Muhibur Rasheed is with UT Austin; Maysam Moussalem is with UT Austin; Donald Keidel is with The Scripps Research Institute; Arthur Olson is with The Scripps Research Institute; Michel Sanner is with The Scripps ...
Bajaj, Chandrajit, Chowdhury, Rezaul, Keidel, Donald, Moussalem, Maysam, Olson, Arthur, Rasheed, Muhibur, Sanner, Michel   +6 more
core   +4 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins

Scientific Reports, 2019
DNA replication is initiated at replication origins on chromosomes at their scheduled time during S phase of the cell cycle. Replication timing control is highly conserved among eukaryotes but the underlying mechanisms are not fully understood.
Yudai Hasegawa, Mayuko Yamamoto, Junki Miyamori, Junko Kanoh   +3 more
doaj   +1 more source

Latent protein trees [PDF]

, 2013
Unbiased, label-free proteomics is becoming a powerful technique for measuring protein expression in almost any biological sample. The output of these measurements after preprocessing is a collection of features and their associated intensities for each ...
Carin, Lawrence, Ginsburg, Geoffrey S., Henao, Ricardo, Lucas, Joseph E., Moseley, M. Arthur, Thompson, J. Will   +5 more
core   +2 more sources

INTRINSIC PROTEIN DISORDER AND PROTEIN-PROTEIN INTERACTIONS [PDF]

Biocomputing 2012, 2011
Intrinsically disordered proteins often bind to more than one partner. In this study, we focused on 11 sets of complexes in which the same disordered segment becomes bound to two or more distinct partners. For this collection of protein complexes, two or more partners of each disordered segment were selected to have less than 25% amino acid identity ...
Wei-Lun, Hsu, Christopher, Oldfield, Jingwei, Meng, Fei, Huang, Bin, Xue, Vladimir N, Uversky, Pedro, Romero, A Keith, Dunker   +7 more
openaire   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Intracellular C3 regulates the immune response to infection via NF-κB signaling

Cellular and Molecular Life Sciences
Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment.
Katarzyna Kuska, Serena Bettoni, Frida Mohlin, Maja Chrobak, Vaishnavi Dandavate, Saleh Moradi, Ben King, Kristian Riesbeck, Anna M. Blom   +8 more
doaj   +1 more source

A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis

Communications Biology, 2023
Biophysical approaches reveal how a mutation in the constant light chain domain of a patient-derived antibody destabilizes the constant domain, prevents the dimerization of the light chain, and makes it more prone to proteolytic cleavage, unleashing the ...
Georg J. Rottenaicher, Ramona M. Absmeier, Laura Meier, Martin Zacharias, Johannes Buchner   +4 more
doaj   +1 more source