Results 101 to 110 of about 7,628,689 (242)
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity [PDF]
, 2015 Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are ...
Andrade-Navarro, Miguel A. +24 more
core +2 more sources
Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]
, 2019 Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal +4 more
core
REACTIVITY OF CHLOROPHYLL a/b-PROTEINS AND MICELLAR TRITON X-100 COMPLEXES OF CHLOROPHYLLS a OR b WITH BOROHYDRIDE [PDF]
, 1989 The reaction of several plant chlorophyll-protein complexes with NaBH4 has been studied by absorption spectroscopy. In all the complexes studied, chlorophyll b is more reactive than Chi a, due to preferential reaction of its formyl substituent at C-7 ...
Arnon D. I. +15 more
core +1 more source
Stop-and-go kinetics in amyloid fibrillation [PDF]
, 2009 Many human diseases are associated with protein aggregation and fibrillation. Using glucagon as a model system for protein fibrillation we show that fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. Remarkably, even
Christian Beyschau Andersen +10 more
core +5 more sources
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease
Frontiers in Pharmacology, 2019 Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein ...
J. M. Webster +3 more
semanticscholar +1 more source
Self-Templated Nucleation in Peptide and Protein aggregation
, 2008 Peptides and proteins exhibit a common tendency to assemble into highly ordered fibrillar aggregates, whose formation proceeds in a nucleation-dependent manner that is often preceded by the formation of disordered oligomeric assemblies.
Amos Maritan +5 more
core +1 more source
Size-Controlled Water-Soluble Ag Nanoparticles [PDF]
, 2007 Ag nanoparticles of two different sizes (1 and 4 nm) were prepared within an apoferritin cavity by using an Ag+-loaded apoferritin as a nanoconfined environment for their construction.
Calvino Gámez, José Juan +6 more
core +2 more sources
BMC Neuroscience, 2017 BackgroundIn the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the microglial cells, delivering drugs ...
Zahra Yarjanli +4 more
semanticscholar +1 more source
Protein aggregation in Huntington’s disease
Biochimie, 2002 The presence of an expanded polyglutamine produces a toxic gain of function in huntingtin. Protein aggregation resulting from this gain of function is likely to be the cause of neuronal death. Two main mechanisms of aggregation have been proposed: hydrogen bonding by polar-zipper formation and covalent bonding by transglutaminase-catalyzed cross ...
Hoffner, Guylaine, Djian, Philippe
openaire +3 more sources