Results 111 to 120 of about 7,628,689 (242)

Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]

Journal of Excipients and Food Chemicals
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj  

NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

Nature Communications, 2018
Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/
Chantal M. Maghames, S. Lobato-Gil, Aurélien Perrin, Helene Trauchessec, Manuel S. Rodríguez, S. Urbach, P. Marin, Dimitris P. Xirodimas   +7 more
semanticscholar   +1 more source

Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

G3: Genes, Genomes, Genetics, 2018
A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify the ...
Theodore W. Peters, Christopher S. Nelson, Akos A. Gerencser, Kathleen J. Dumas, Brandon Tavshanjian, Kyu Chul Chang, Gordon J. Lithgow, Robert E. Hughes   +7 more
doaj   +1 more source

Impact of Cavitation, High Shear Stress and Air/Liquid Interfaces on Protein Aggregation.

Biotechnology Journal, 2018
The reported impact of shear stress on protein aggregation has been contradictory. At high shear rates, the occurrence of cavitation or entrapment of air is reasonable and their effects possibly misattributed to shear stress.
M. Duerkop, E. Berger, A. Dürauer, A. Jungbauer   +3 more
semanticscholar   +1 more source

Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & aims: Gastroesophageal reflux disease (GERD) is a common digestive disorder that is characterized by esophageal tissue damage produced by exposure of the esophageal lining to the gastric refluxate.
Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika   +10 more
doaj   +1 more source

Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

Journal of Pharmaceutical Analysis, 2018
Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle ...
Kevin P. Kent, Chad E. Schroeder, Chandana Sharma   +2 more
doaj   +1 more source

Aggregation Prediction in Therapeutic Protein Formulations for Excipient Design [PDF]

, 2010
Computational Infrastructure & Informatics Poster SessionA major concern in the development therapeutic protein formulations is protein aggregation. Proteins can interact to form bound groups of protein molecules or aggregates.
Camarda, K. V., Laurence, J., Pokphanh, Anthony I., Reynolds, T. Steele, Roughton, Brock C., Topp, E. M.   +5 more
core  

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

FEBS Letters, 2018
Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain.
A. Maïza, S. Chantepie, C. Vera, A. Fifre, M. B. Huynh, O. Stettler, M. Ouidja, D. Papy-Garcia   +7 more
semanticscholar   +1 more source

Refolding protein aggregates [PDF]

Science, 2016
Polymers Although protein chaperones direct the correct folding of nascent proteins, they also can resolubilize protein aggregates that may have formed to enable their refolding. Polymers such as poly(ethylene glycol) can help keep proteins in their native state by preventing thermal denaturation and aggregation. Nakamoto et al.
openaire   +1 more source

Protein aggregation: in silico algorithms and applications

Biophysical Reviews, 2021
R. Prabakaran, P. Rawat, A. M. Thangakani, Sandeep Kumar, M. M. Gromiha   +4 more
semanticscholar   +1 more source