Results 131 to 140 of about 436,505 (303)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Characterization of Protein Aggregation via Intrinsic Fluorescence Lifetime

, 2016
Characterization of Protein Aggregation via Intrinsic Fluorescence ...
Candace K. Lange (2335903), Gregory D. Gillispie (2335900), Kristian H. Schlick (1731805), Mary J. Cloninger (1731799)   +3 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Material surface-induced protein aggregation in the context of shear: From pathophysiological significance to biopharmaceutical implications

Next Materials
Protein misfolding and aggregation can lead to several disease states and can significantly impact the biopharmaceutical processes of biological therapeutics. While shear-stress and surface adsorption are known to contribute to protein aggregation, these
Shabeena Jegamohan, Maziar Jafari, Marc-Antoine Lauzon, Theo G.M. van de Ven, Steve Bourgault, Roger Gaudreault   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Sequential and structural deteminants of protein aggregation [PDF]

, 2010
Descripció del recurs: el 1 de febrer de 2011The project entitled "Sequential and structural determinants of protein aggregation" aims to study the factors that control protein deposition but also tries to develop new strategies to facilitate its ...
Sánchez de Groot, Natalia, Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular   +1 more
core  

Lanosterol reverses protein aggregation in cataracts

, 2015
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index.
Ouyang, Hong, Chen, Xiang-Jun, Qiu, Austin, Zhao, Ling, Yang, Xu, Patel, Sherrina H., Jin, Xin, Wen, Cindy, Abagyan, Ruben, Wang, Yandong, Hou, Rui, Yeh, Emily, Lin, Ying, Hu, Xun, Cao, Guiqun, Hu, Li-Dan, Luo, Hongrong, Lin, Danni, Wu, Frances, Xi, Yi-Bo, Flagg, Ken, Wang, Wenqiu, Grob, Seanna, Su, Zhiguang, Tjondro, Harry Christianto, Cai, Huimin, Chen, Daniel, Zhao, Xi-Juan, Chung, Christopher, Li, Gen, Zhu, Jie   +30 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source