Results 51 to 60 of about 737,165 (295)

Aging and the aggregating proteome

Frontiers in Genetics, 2012
For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein ...
Della C David
doaj   +1 more source

FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative illness that is unremittingly fatal and for which no effective treatment exists. All forms of ALS are characterized by protein aggregation.
Hiroaki Kaku, Hiroaki Kaku, Alexander V. Ludlow, Michael F. Gutknecht, Thomas L. Rothstein, Thomas L. Rothstein   +5 more
doaj   +1 more source

Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation. [PDF]

PLoS ONE, 2009
Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Kurt Forrer, Heidi Zhang, Cornelius Fritsch, Holger Heine, Bernhardt L Trout   +8 more
doaj   +1 more source

Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases

Metabolites, 2023
Protein aggregation is the etiopathogenesis of the three most profound vision-threatening eye diseases: age-related cataract, presbyopia, and age-related macular degeneration.
Jack V. Greiner, Thomas Glonek
doaj   +1 more source

Protein aggregates in Huntington's disease [PDF]

Experimental Neurology, 2012
Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats.
Arrasate, Montserrat, Finkbeiner, Steven
openaire   +4 more sources

Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells

Frontiers in Chemistry, 2019
In general, neurodegenerative disorders have a great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules.
Anzar Abdul Mujeeb, Khan Farheen Badre Alam, Ansam Wadia Faid Alshameri, Fauzia Jamal, Saba Farheen, Mohd Kashif, Anees Ahmed, Irfan Ahmad Ghazi, Mohammad Owais   +8 more
doaj   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Data on correlation between Aβ42 structural aggregation propensity and toxicity in bacteria

Data in Brief, 2016
Protein aggregation and amyloid formation is a hallmark of an increasing number of human disorders. Because protein aggregation is deleterious for the cell physiology and results in a decrease in overall cell fitness, it is thought that natural selection
Anita Carija, Susanna Navarro, Salvador Ventura   +2 more
doaj   +1 more source

The amyloid interactome: Exploring protein aggregation. [PDF]

PLoS ONE, 2017
Protein-protein interactions are the quintessence of physiological activities, but also participate in pathological conditions. Amyloid formation, an abnormal protein-protein interaction process, is a widespread phenomenon in divergent proteins and ...
Konstantina V Biza, Katerina C Nastou, Paraskevi L Tsiolaki, Chara V Mastrokalou, Stavros J Hamodrakas, Vassiliki A Iconomidou   +5 more
doaj   +1 more source

Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks

, 2011
Topological network motifs represent functional relationships within and between regulatory and protein-protein interaction networks. Enriched motifs often aggregate into self-contained units forming functional modules.
Anagha Joshi, Björklund, Brin, Bruno Nachtergaele, Csikász-Nagy, De Lathauwer, de Lichtenberg, Dobrin, Fiedler, Harbison, Hartwell, Huang, Kalir, Kashtan, Kashtan, Kellog, Kleinberg, Kraemer, Lee, Lee, Loch, Mazurie, McClellan, Mendenhall, Milo, Neely, Newman, Planta, Ptacek, Ravasz, Reguly, Shen-Orr, Solé, Solé, Spellman, Stark, Tan, Tom Michoel, Vázquez, Yeger-Lotem, Yeger-Lotem, Yosef, Yu, Yves Van de Peer, Zhang, Zhao   +45 more
core   +2 more sources