Results 251 to 260 of about 559,282 (295)
Some of the next articles are maybe not open access.
Large-scale functional analysis using peptide or protein arrays
Nature Biotechnology, 2000The array format for analyzing peptide and protein function offers an attractive experimental alternative to traditional library screens. Powerful new approaches have recently been described, ranging from synthetic peptide arrays to whole proteins expressed in living cells.
A Q, Emili, G, Cagney
openaire +2 more sources
MULTIPLEXED PROTEIN ARRAY PLATFORMS FOR ANALYSIS OF AUTOIMMUNE DISEASES
Annual Review of Immunology, 2006Several proteomics platforms have emerged in the past decade that show great promise for filling in the many gaps that remain from earlier studies of the genome and from the sequencing of the human genome itself. This review describes applications of proteomics technologies to the study of autoimmune diseases.
Imelda, Balboni +5 more
openaire +2 more sources
Single-Molecule Arrays for Protein and Nucleic Acid Analysis
Annual Review of Analytical Chemistry, 2017The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement of analytes of interest into ultrasmall containers have greatly enhanced the sensitivity and throughput of many detection methods. Fabrication of microwell arrays and implementation of bead-based
Limor, Cohen, David R, Walt
openaire +2 more sources
Experimental Design & Analysis of Protein Array Data: Applying Methods from cDNA Arrays.
Blood, 2004Abstract It appears that a number of recent manuscripts using protein microarray technology are using equivalent analysis procedures that the gene-expression microarray community implemented in their infancy. That is, utilizing a classic reference design such that the ratio of the sample of interest to a reference sample is the response ...
Irene Ghobrial +2 more
openaire +1 more source
Protein chip array profiling analysis of sera from neuroblastoma patients
Cancer Letters, 2005Neuroblastoma, the most common extracranial solid tumour in children, is characterised by highly heterogeneous clinical behaviour; patients are stratified into risk categories according to a combination of clinical and biological markers. However, identifying non-invasive prognostic markers predicting outcome independently from current risk ...
Valérie, Combaret +6 more
openaire +2 more sources
Network-based analysis of reverse phase protein array data
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2016In this paper, we introduce a computational method for constructing networks based on reverse phase protein array (RPPA) data to identify complex patterns in protein signaling. The method is applied to phosphoproteomic profiles of basal expression and activation/phosphorylation of 76 key signaling proteins in three breast cancer cell lines (MCF7, LCC1,
Rency S Varghese +8 more
openaire +1 more source
Large-Scale Analysis of Protein–Protein Interactions Using Cellulose-Bound Peptide Arrays
2008Peptide arrays for screening large numbers of peptide fragments and probing with large numbers of samples is discussed.
Ulrike, Beutling +3 more
openaire +2 more sources
The Channel Array Interrogation (CAI) instrument for C-reactive protein analysis
2011 International Workshop on Biophotonics, 2011A Channel Array Interrogation (CAI) instrument for multiparameter-analysis has been developed. In particular, the portable device was optimized for the C-reactive protein (CRP), one of the analytes of interest for sepsis.
AGiannetti +4 more
openaire +1 more source
Analysis of Protein–Protein Interactions Using Array-Based Yeast Two-Hybrid Screens
2009The yeast two-hybrid system (Y2H) is a powerful tool to identify protein-protein interactions. Here we describe array-based two-hybrid methods that use defined libraries of open reading frames (ORFs) as opposed to random genomic or cDNA libraries. The array-based Y2H system is well suited for interactome studies of existing ORFeomes or subsets thereof,
Seesandra V, Rajagopala, Peter, Uetz
openaire +2 more sources
Cold Spring Harbor Protocols, 2006
INTRODUCTIONThe most difficult aspect of using an array approach for a high-throughput study is maintaining the array’s viability while avoiding contamination of the plates. This protocol describes three different storage methods for the array. Frozen stocks are the most permanent method and are an absolute requirement for maintaining a record of the ...
Tony R, Hazbun, John P, Miller
openaire +2 more sources
INTRODUCTIONThe most difficult aspect of using an array approach for a high-throughput study is maintaining the array’s viability while avoiding contamination of the plates. This protocol describes three different storage methods for the array. Frozen stocks are the most permanent method and are an absolute requirement for maintaining a record of the ...
Tony R, Hazbun, John P, Miller
openaire +2 more sources