Results 301 to 310 of about 583,434 (343)

MULTIPLEXED PROTEIN ARRAY PLATFORMS FOR ANALYSIS OF AUTOIMMUNE DISEASES

Annual Review of Immunology, 2006
Several proteomics platforms have emerged in the past decade that show great promise for filling in the many gaps that remain from earlier studies of the genome and from the sequencing of the human genome itself. This review describes applications of proteomics technologies to the study of autoimmune diseases.
Imelda, Balboni, Steven M, Chan, Michael, Kattah, Jessica D, Tenenbaum, Atul J, Butte, Paul J, Utz   +5 more
openaire   +2 more sources

Single-Molecule Arrays for Protein and Nucleic Acid Analysis

Annual Review of Analytical Chemistry, 2017
The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement of analytes of interest into ultrasmall containers have greatly enhanced the sensitivity and throughput of many detection methods. Fabrication of microwell arrays and implementation of bead-based
Limor, Cohen, David R, Walt
openaire   +2 more sources

RPPApipe: A pipeline for the analysis of reverse-phase protein array data

Biosystems, 2014
Today, web-based data analysis pipelines exist for a wide variety of microarray platforms, such as ordinary gene-centered arrays, exon arrays and SNP arrays. However, most of the available software tools provide only limited support for reverse-phase protein arrays (RPPA), as relevant inherent properties of the corresponding datasets are not taken into
Eichner, Johannes; Heubach, Yvonne; Ruff, Manuel; Kohlhof, Hella; Strobl, Stefan; Mayer, Barbara; Pawlak, Michael; Templin, Markus F.; Zell, Andreas   +9 more
openaire   +3 more sources

Vertical nanowire arrays as a versatile platform for protein detection and analysis

Nanoscale, 2013
Protein microarrays are valuable tools for protein assays. Reducing spot sizes from micro- to nano-scale facilitates miniaturization of platforms and consequently decreased material consumption, but faces inherent challenges in the reduction of fluorescent signals and compatibility with complex solutions. Here we show that vertical arrays of nanowires (
Rostgaard, Katrine R., Frederiksen, Rune S., Liu, Yi-Chi, Berthing, Trine, Madsen, Morten H., Holm, Johannes, Nygård, Jesper, Martinez, Karen L.   +7 more
openaire   +3 more sources

Patterns of protein expression in infectious meningitis: A cerebrospinal fluid protein array analysis

Journal of Neuroimmunology, 2005
Seventy-nine cytokines, chemokines, and growth factors were measured by protein array analysis in the cerebrospinal fluid of patients with meningitis and controls. Several factors were found to be regulated, which have not been studied in the CNS before, e.g., macrophage inflammatory protein-1delta (CCL15) and neutrophil-activating peptide-2 (CXCL7 ...
Barbara Angele, Hans-Walter Pfister, Uwe Koedel   +2 more
exaly   +3 more sources

Large-scale functional analysis using peptide or protein arrays

Nature Biotechnology, 2000
The array format for analyzing peptide and protein function offers an attractive experimental alternative to traditional library screens. Powerful new approaches have recently been described, ranging from synthetic peptide arrays to whole proteins expressed in living cells.
A Q, Emili, G, Cagney
openaire   +2 more sources

The Use of Electron Tomography for Structural Analysis of Disordered Protein Arrays

Journal of Structural Biology, 1997
A method based on Fourier transforms is described for obtaining a 3-D reconstruction from a paracrystalline object with static disorder. The method is derived from the standard methods used in 3-D reconstruction of 2-D crystals except that all of the Fourier coefficients are used and not just the sampled data from the periodic lattice.
K A, Taylor, J, Tang, Y, Cheng, H, Winkler   +3 more
openaire   +2 more sources

Network-based analysis of reverse phase protein array data

2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2016
In this paper, we introduce a computational method for constructing networks based on reverse phase protein array (RPPA) data to identify complex patterns in protein signaling. The method is applied to phosphoproteomic profiles of basal expression and activation/phosphorylation of 76 key signaling proteins in three breast cancer cell lines (MCF7, LCC1,
Rency S. Varghese, Yiming Zuo 0002, Yi Zhao, Yong-Wei Zhang, Sandra A. Jablonski, Mariaelena Pierobon, Emanuel F. Petricoin, Habtom W. Ressom, Louis M. Weiner   +8 more
openaire   +1 more source

Analysis of Autoantibody Profiles in Osteoarthritis Using Comprehensive Protein Array Concepts

Journal of Proteome Research, 2014
Osteoarthritis (OA) is the most common rheumatic disease and one of the most disabling pathologies worldwide. To date, the diagnostic methods of OA are very limited, and there are no available medications capable of halting its characteristic cartilage degeneration.
Henjes F, Lourido L, Ruiz-Romero C, Fernández-Tajes J, Schwenk JM, Gonzalez-Gonzalez M, Blanco FJ, Nilsson P, Fuentes M   +8 more
openaire   +4 more sources

The Channel Array Interrogation (CAI) instrument for C-reactive protein analysis

2011 International Workshop on Biophotonics, 2011
A Channel Array Interrogation (CAI) instrument for multiparameter-analysis has been developed. In particular, the portable device was optimized for the C-reactive protein (CRP), one of the analytes of interest for sepsis.
AGiannetti, C Trono, F Baldini, L Bolzoni, G Porro   +4 more
openaire   +1 more source