Results 11 to 20 of about 9,359,328 (318)
Pharmaceuticals, 2021 Plasma protein binding is an important determinant of the pharmacokinetic properties of chemical compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatographic experiments.
Karolina Wanat +3 more
doaj +1 more source
Reducing Unspecific Protein Adsorption in Microfluidic Papers Using Fiber-Attached Polymer Hydrogels
Sensors, 2021 Microfluidic paper combines pump-free water transport at low cost with a high degree of sustainability, as well as good availability of the paper-forming cellulosic material, thus making it an attractive candidate for point-of-care (POC) analytics and ...
Alexander Ritter von Stockert +6 more
doaj +1 more source
PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding
Biosensors, 2023 The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable ...
Marjorie Montero-Jimenez +5 more
doaj +1 more source
Applied Sciences, 2021 Platinum (Pt) antineoplastic agents remain indispensable for the treatment of oncological disease. Pt-based drugs are mainly used in the therapy of ovarian cancer and non-small-cell lung carcinoma.
Elena Fedoros +4 more
doaj +1 more source
An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans +8 more
doaj +1 more source
Largazole Pharmacokinetics in Rats by LC-MS/MS
Marine Drugs, 2014 A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu +9 more
doaj +1 more source
Nucleic Acids Res., 2018 The structural states of proteins include ordered globular domains as well as intrinsically disordered protein regions that exist as highly flexible conformational ensembles in isolation.
Bálint Mészáros +2 more
semanticscholar +1 more source
mBio, 2017 The type 3 secretion system (T3SS) is essential for bacterial virulence through delivering effector proteins directly into the host cytosol. Here, we identified an alternative delivery mechanism of virulence factors mediated by the T3SS, which consists ...
Farid Tejeda-Dominguez +3 more
doaj +1 more source
A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA
Clinical, Cosmetic and Investigational Dermatology, 2023 David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide, Amy D Brideau-Andersen Allergan Aesthetics, an AbbVie Company, Irvine, CA, USACorrespondence: David C Rupp, Allergan Aesthetics, an AbbVie Company, 2525 Dupont
Rupp DC +6 more
doaj
Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent
Marine Drugs, 2010 Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold,
Ruiwen Zhang +11 more
doaj +1 more source