Results 191 to 200 of about 11,837,096 (346)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Photoswitchable intein for light control of covalent protein binding and cleavage. [PDF]

Nat Commun
Baloban M, Manoilov KY, Karasev MM, Verkhusha VV, Shcherbakova DM.   +4 more
europepmc   +1 more source

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.

Cell, 2010
M. Hafner, M. Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, Philipp Berninger, Andrea Rothballer, M. Ascano, Anna-Carina Jungkamp, Mathias Munschauer, Alexander Ulrich, G. Wardle, Scott B. Dewell, M. Zavolan, T. Tuschl   +14 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

<i>De Novo</i> Design of Protein-Binding Peptides by Quantum Computing. [PDF]

J Chem Theory Comput
Meuser L, Patsilinakos A, Faccioli P.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

EPIclip: A Novel Approach for the Production of Decorated Virus-Like Particles Mediated by High-Affinity Protein Binding Partners. [PDF]

Vaccines (Basel)
Moleda A, Bagshaw O, Repkewitz J, Ahmed S, Jakab A, Gomez Jordan P, Sunny S, Bourdon JC, Foerster J.   +8 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Exploiting Avidity Effects for the Discovery of Low Affinity Protein-Binding Fragments. [PDF]

J Med Chem
Jayalath IM, Beckwith D, Yoon J, Liu X, Kodadek T.   +4 more
europepmc   +1 more source

PRODIGY: a web server for predicting the binding affinity of protein-protein complexes

Bioinform., 2016
L. Xue, J. Rodrigues, P. Kastritis, A. Bonvin, A. Vangone   +4 more
semanticscholar   +1 more source