Results 201 to 210 of about 4,419,405 (356)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G‑Quadruplexes and Their Protein Binding Partners. [PDF]

ACS Bio Med Chem Au
Raevens S, Danino YM, Desingle C, Rota Sperti F, Pirrotta M, Mazzucotelli L, Letissier L, Hornstein E, Cianferani S, Hernandez-Alba O, Valverde IE, Monchaud D.   +11 more
europepmc   +1 more source

Binding affinity of pAPN with the S proteins of PEDV, TGEV, and SADS-CoV revealed by docking structure and SPR.

Da An (21627567), Yan Li (23143), Yi Pei (54574), Yong-Hao Ma (2869658), Fei Yao (43685), Yongzhi Feng (11861457), Yanke Shan (5978276), Fei Liu (21082)   +7 more
openalex   +1 more source

Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells [PDF]

, 1998
Mauro R. Tucci, Karen Nygard, B. Tanswell, Harrison W. Farber, DJ Hill, VK Han   +5 more
openalex   +1 more source

Protein-protein interactions and reduced excluded volume increase dynamic binding capacity of dual salt systems in hydrophobic interaction chromatography

, 2021
Leo A. Jakob, Beate Beyer, Catarina Janeiro Ferreira, Nico Lingg, Alois Jungbauer, Rupert Tscheließnig   +5 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

MPBind: a multitask protein binding site predictor using protein language models and equivariant GNNs. [PDF]

Bioinformatics
Wang Y, Boadu F, Cheng J.
europepmc   +1 more source

Mac-2 binding protein glycosylation isomer as a novel serum biomarker for recurrence in hepatocellular carcinoma

Kyle R Stephens, Megan Wilson, Manting Xu, Jeremy T Gaskins, Gina Genova, Robert C G Martin II   +5 more
openalex   +1 more source

Structure-Function Analysis of the Heat Shock Factor-binding Protein Reveals a Protein Composed Solely of a Highly Conserved and Dynamic Coiled-coil Trimerization Domain [PDF]

, 2002
Li-Jung Tai, Sally M. McFall, Kai Huang, Borries Demeler, Sue G. Fox, K. Brubaker, Ishwar Radhakrishnan, Richard I. Morimoto   +7 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source