Results 231 to 240 of about 4,419,405 (356)

Amino acids within the extracellular matrix (ECM) binding region (201-218) of rat insulin-like growth factor binding protein (IGFBP)-5 are important determinants in binding IGF-I [PDF]

, 1999
Silvia Bramani, Hyuk Song, James Beattie, Elizabeth Tonner, Diane J Flint, GJ Allan   +5 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Reliable prediction of protein-protein binding affinity changes upon mutations with Pythia-PPI. [PDF]

Natl Sci Rev
Tao F, Sun J, Gao P, Gao GF, Wu B.
europepmc   +1 more source

Phosphorylation of Thyroid Hormone Receptors by Protein Kinase A Regulates DNA Recognition by Specific Inhibition of Receptor Monomer Binding [PDF]

, 1998
Christina Tzagarakis-Foster, Martin L. Privalsky   +1 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

VN-EGNN: E(3)- and SE(3)-Equivariant Graph Neural Networks with Virtual Nodes Enhance Protein Binding Site Identification. [PDF]

J Cheminform
Sestak F, Schneckenreiter L, Brandstetter J, Hochreiter S, Mayr A, Klambauer G.   +5 more
europepmc   +1 more source

α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Subunit Composition and cAMP-response Element-binding Protein Regulate Oligodendrocyte Excitotoxicity

, 2006
Wenbin Deng, Rachael L. Neve, Paul A. Rosenberg, Joseph J. Volpe, Frances E. Jensen   +4 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Multifunctional N-substituted 2-pyridylbenzothiazole derivatives: singlet oxygen generation, protein binding, and photoactivated anticancer and antibacterial activities. [PDF]

RSC Adv
Mohamed HA, Abdel-Shafi AA, Miyatake H, El-Khouly ME, Nassrallah AA.   +4 more
europepmc   +1 more source

Low expression levels of insulin-like growth factor binding protein-3 are correlated with poor prognosis for patients with hepatocellular carcinoma

, 2017
Jinjin Yan, XINZHENG YANG, Lin Li, Pengtao Liu, Honghui Wu, Zhanao Liu, Qingyi Li, GUOZHEN LIAO, Xinlong Wang   +8 more
openalex   +2 more sources