Results 251 to 260 of about 4,079,288 (357)

Physicochemical Studies on the Binding of Chemicals with Proteins. II

, 1964
Masayuki Nakagaki, Naofumi Koga, Hiroshi Terada   +2 more
openalex   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Inferring differential protein binding from time-series chromatin accessibility data. [PDF]

Bioinform Adv
Mitra S, Hartemink AJ.
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

SpatConv Enables the Accurate Prediction of Protein Binding Sites by a Pretrained Protein Language Model and an Interpretable Bio-spatial Convolution. [PDF]

Research (Wash D C)
Guan M, Han J, Zhang S, Zheng H, Liu J.
europepmc   +1 more source

PROTEIN AND LIPID BINDING OF VOLATILE ANAESTHETIC AGENTS

, 1964
R. M. Featherstone, B. P. Schoenborn
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry. [PDF]

Microbiol Spectr
Chen W, Lee J-Y, Kim J-S, Shin JS, Fung TS, Yeh J-Y, Chen Z, Zhou B, Song J-J, Go YY.   +9 more
europepmc   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source

Genome-wide mapping of cAMP receptor protein binding in enteroaggregative <i>Escherichia coli</i> reveals targeting of virulence-associated genes. [PDF]

Microbiology (Reading)
Alhammadi MM, Hothersall J, Lloyd GS, Titman SV, Guest T, Browning DF, Grainger DC, Busby SJW, Haycocks JRJ.   +8 more
europepmc   +1 more source