Results 261 to 270 of about 4,419,405 (356)

Protein Binding Site Representation in Latent Space. [PDF]

Mol Inform
Lohmann F, Allenspach S, Atz K, Schiebroek CCG, Hiss JA, Schneider G.   +5 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Estimating Absolute Protein-Protein Binding Free Energies by a Super Learner Model. [PDF]

J Chem Inf Model
Chaves EJF, Sartori J, Santos WM, Cruz CHB, Mhrous EN, Nacimento-Filho MF, Ferraz MVF, Lins RD.   +7 more
europepmc   +1 more source

Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins

, 1998
Paul E. Mead, Yi Zhou, Kevin D. Lustig, Tara L. Huber, Marc W. Kirschner, Leonard I. Zon   +5 more
openalex   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning. [PDF]

Nat Chem Biol
Rettie SA, Juergens D, Adebomi V, Bueso YF, Zhao Q, Leveille AN, Liu A, Bera AK, Wilms JA, Üffing A, Kang A, Brackenbrough E, Lamb M, Gerben SR, Murray A, Levine PM, Schneider M, Vasireddy V, Ovchinnikov S, Weiergräber OH, Willbold D, Kritzer JA, Mougous JD, Baker D, DiMaio F, Bhardwaj G.   +25 more
europepmc   +1 more source

Alleviation of Human Papillomavirus E2-Mediated Transcriptional Repression via Formation of a TATA Binding Protein (or TFIID)-TFIIB-RNA Polymerase II-TFIIF Preinitiation Complex

, 2000
Samuel Y. Hou, Shwu-Yuan Wu, Tianyuan Zhou, Mary C. Thomas, Cheng-Ming Chiang   +4 more
openalex   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding.

Phys Chem Chem Phys
Palmisano VF, Agnorelli C, Faraji S, Nogueira JJ.   +3 more
europepmc   +1 more source

Correction: DiffBP: generative diffusion of 3D molecules for target protein binding. [PDF]

Chem Sci
Lin H, Huang Y, Zhang O, Ma S, Liu M, Li X, Wu L, Ji S, Hou T, Li SZ.   +9 more
europepmc   +1 more source