Results 261 to 270 of about 11,837,096 (346)

Correction: DiffBP: generative diffusion of 3D molecules for target protein binding. [PDF]

Chem Sci
Lin H, Huang Y, Zhang O, Ma S, Liu M, Li X, Wu L, Ji S, Hou T, Li SZ.   +9 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Improved Prediction of Ligand-Protein Binding Affinities by Meta-modeling. [PDF]

J Chem Inf Model
Lee HJ, Emani PS, Gerstein MB.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning. [PDF]

Nat Chem Biol
Rettie SA, Juergens D, Adebomi V, Bueso YF, Zhao Q, Leveille AN, Liu A, Bera AK, Wilms JA, Üffing A, Kang A, Brackenbrough E, Lamb M, Gerben SR, Murray A, Levine PM, Schneider M, Vasireddy V, Ovchinnikov S, Weiergräber OH, Willbold D, Kritzer JA, Mougous JD, Baker D, DiMaio F, Bhardwaj G.   +25 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Insights into interspecies protein binding variability using clindamycin as an example. [PDF]

J Antimicrob Chemother
Ahmed H, Böhmdorfer M, Jäger W, Zeitlinger M.   +3 more
europepmc   +1 more source

Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease. [PDF]

Nat Commun
Ouyang Q, Su J, Li Y, Liao H, Guo H, Sun Y, Wang X, Chen J, Thinwa J, Ding WX, Tilg H, Ren F, Zhang H, Liu R.   +13 more
europepmc   +1 more source

Global analysis of excitotoxicity-induced alterations in RNA structure and RNA-protein binding in neurons. [PDF]

iScience
Alvarez-Periel E, Kramer MC, Akay-Espinoza C, Jackson DP, Tasca JA, Garcia BA, Gregory BD, Jordan-Sciutto KL.   +7 more
europepmc   +1 more source