Results 21 to 30 of about 4,419,405 (356)
The Cell Density Factor CMF Regulates the Chemoattractant Receptor cAR1 in Dictyostelium [PDF]
, 1996 Starving Dictyostelium cells aggregate by chemotaxis to cAMP when a secreted protein called conditioned medium factor (CMF) reaches a threshold concentration.
Bishop, John D., +2 more
core +11 more sources
Pharmaceutics, 2022 Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov +10 more
doaj +1 more source
A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
Biomolecules, 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy +2 more
doaj +1 more source
Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]
, 1994 Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan +29 more
core +1 more source
Osteoarthritis and Cartilage, 2001 The connective tissues are crucial for multicellular organisms, playing many diverse roles both structurally and mechanically as well as providing a protective function. They make up the frame of the mammalian body and add strength and elasticity, while their protective function is important both on the outside of the body and inside, where they ...
Svensson, L. +2 more
openaire +2 more sources
The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]
, 2016 Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee +44 more
core +1 more source
Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
doaj +1 more source
Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology
Frontiers in Medicine, 2021 Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial
Lionel Sebbag +5 more
doaj +1 more source
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]
, 2017 Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S. +14 more
core +1 more source
Journal of Cell Science, 2005 Actin is an essential component of the cytoskeleton and plays a crucial role in eukaryotic cells. The actin cytoskeleton functions in the generation and maintenance of cell morphology and polarity, in endocytosis and intracellular trafficking, in contractility, motility and cell division. In cells,
Steven J, Winder, Kathryn R, Ayscough
openaire +2 more sources