Results 21 to 30 of about 10,846,120 (403)
Biological barriers, and the influence of protein binding on the passage of drugs across them
Molecular Biology Reports, 2020 Drug-protein binding plays a key role in determining the pharmacokinetics of a drug. The distribution and protein binding ability of a drug changes over a lifetime, and are important considerations during pregnancy and lactation.
Karolina Wanat
semanticscholar +1 more source
Anais da Academia Brasileira de Ciências, 2021 Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects.
PEDRO HENRIQUE SETTE-DE-SOUZA +4 more
doaj +1 more source
Pharmaceuticals, 2021 Plasma protein binding is an important determinant of the pharmacokinetic properties of chemical compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatographic experiments.
Karolina Wanat +3 more
doaj +1 more source
Reducing Unspecific Protein Adsorption in Microfluidic Papers Using Fiber-Attached Polymer Hydrogels
Sensors, 2021 Microfluidic paper combines pump-free water transport at low cost with a high degree of sustainability, as well as good availability of the paper-forming cellulosic material, thus making it an attractive candidate for point-of-care (POC) analytics and ...
Alexander Ritter von Stockert +6 more
doaj +1 more source
PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding
Biosensors, 2023 The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable ...
Marjorie Montero-Jimenez +5 more
doaj +1 more source
Applied Sciences, 2021 Platinum (Pt) antineoplastic agents remain indispensable for the treatment of oncological disease. Pt-based drugs are mainly used in the therapy of ovarian cancer and non-small-cell lung carcinoma.
Elena Fedoros +4 more
doaj +1 more source
An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans +8 more
doaj +1 more source
Largazole Pharmacokinetics in Rats by LC-MS/MS
Marine Drugs, 2014 A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu +9 more
doaj +1 more source
Nucleic Acids Res., 2018 The structural states of proteins include ordered globular domains as well as intrinsically disordered protein regions that exist as highly flexible conformational ensembles in isolation.
Bálint Mészáros +2 more
semanticscholar +1 more source
Binding of protein S to C4b-binding protein. Mutagenesis of protein S.
Journal of Biological Chemistry, 1992 Protein S and C4b-binding protein (C4BP) form a tight complex (Kd approximately 0.6 nM) the physiologic purpose of which is unknown. The participation of protein S in this complex was investigated using site-specific mutagenesis. Normal recombinant human protein S (rHPS) and five specifically mutated protein S analogs were expressed in transformed ...
George L. Long, R.M. Nelson
openaire +3 more sources