Results 21 to 30 of about 9,359,328 (318)
Pharmaceutics, 2022 Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov +10 more
doaj +1 more source
Robust transcriptome-wide discovery of RNA binding protein binding sites with enhanced CLIP (eCLIP)
Nature Methods, 2016 As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA molecules, binding site identification by UV crosslinking and immunoprecipitation (CLIP) of ribonucleoprotein complexes is critical to understanding
Eric L. Van Nostrand +13 more
semanticscholar +1 more source
A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
Biomolecules, 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy +2 more
doaj +1 more source
Cellular & Molecular Immunology, 2020 The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory ...
Wanbo Tai +7 more
semanticscholar +1 more source
Bioinform., 2019 Motivation Accurate predictions of protein-binding residues (PBRs) enhances understanding of molecular-level rules governing protein–protein interactions, helps protein–protein docking and facilitates annotation of protein functions.
Jian Zhang, Lukasz Kurgan
semanticscholar +1 more source
bioRxiv, 2018 Motivation Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of ...
Justina Jankauskaite +4 more
semanticscholar +1 more source
Protein-protein binding supersites.
PLoS Computational Biology, 2019 The lack of a deep understanding of how proteins interact remains an important roadblock in advancing efforts to identify binding partners and uncover the corresponding regulatory mechanisms of the functions they mediate.
Raji Viswanathan +4 more
doaj +1 more source
Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology
Frontiers in Medicine, 2021 Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial
Lionel Sebbag +5 more
doaj +1 more source
DeeplyTough: Learning Structural Comparison of Protein Binding Sites
bioRxiv, 2019 Motivation Protein binding site comparison (pocket matching) is of importance in drug discovery. Identification of similar binding sites can help guide efforts for hit finding, understanding polypharmacology and characterization of protein function.
M. Simonovsky, Joshua Meyers
semanticscholar +1 more source
Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
doaj +1 more source