Pharmaceutics, 2022 Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov +10 more
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The structure of an LIM-only protein 4 (LMO4) and deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 [PDF]
, 2016 LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1 ...
Cubeddu, Liza +5 more
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A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
Biomolecules, 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy +2 more
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Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]
, 1994 Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan +29 more
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A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA
Clinical, Cosmetic and Investigational Dermatology, 2023 David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide, Amy D Brideau-Andersen Allergan Aesthetics, an AbbVie Company, Irvine, CA, USACorrespondence: David C Rupp, Allergan Aesthetics, an AbbVie Company, 2525 Dupont
Rupp DC +6 more
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Chemical Reviews, 2013 Arsenic is a trace element found in the earth’s crust at an average concentration of ∼5 μg/g (ppm). Although its relative abundance in the earth’s crust is about 54th, arsenic can become concentrated in some parts of the world because of natural mineralization. Arsenic is a component of 245 minerals, associated most frequently with other metals such as
Xing-Fang Li +4 more
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Photoaffinity Labeling of Plasma Proteins
Molecules, 2013 Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling.
Masaki Otagiri, Victor Tuan Giam Chuang
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The Cell Density Factor CMF Regulates the Chemoattractant Receptor cAR1 in Dictyostelium [PDF]
, 1996 Starving Dictyostelium cells aggregate by chemotaxis to cAMP when a secreted protein called conditioned medium factor (CMF) reaches a threshold concentration.
Bishop, John D., +2 more
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Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
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Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology
Frontiers in Medicine, 2021 Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial
Lionel Sebbag +5 more
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