Results 41 to 50 of about 10,846,120 (403)

Robust transcriptome-wide discovery of RNA binding protein binding sites with enhanced CLIP (eCLIP)

Nature Methods, 2016
As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA molecules, binding site identification by UV crosslinking and immunoprecipitation (CLIP) of ribonucleoprotein complexes is critical to understanding
Eric L. Van Nostrand, G. Pratt, Alexander A. Shishkin, C. Gelboin-Burkhart, Mark Y. Fang, B. Sundararaman, S. Blue, Thai B. Nguyen, Christine Surka, Keri Elkins, Rebecca Stanton, F. Rigo, M. Guttman, Gene W. Yeo   +13 more
semanticscholar   +1 more source

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation

Chemical Reviews, 2018
Huan-Xiang Zhou, Xiaodong Pang
exaly   +2 more sources

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
core   +1 more source

SCRIBER: accurate and partner type-specific prediction of protein-binding residues from proteins sequences

Bioinform., 2019
Motivation Accurate predictions of protein-binding residues (PBRs) enhances understanding of molecular-level rules governing protein–protein interactions, helps protein–protein docking and facilitates annotation of protein functions.
Jian Zhang, Lukasz Kurgan
semanticscholar   +1 more source

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Cellular & Molecular Immunology, 2020
The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory ...
Wanbo Tai, Lei He, Xiujuan Zhang, J. Pu, D. Voronin, Shibo Jiang, Yusen Zhou, L. Du   +7 more
semanticscholar   +1 more source

Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology

Frontiers in Medicine, 2021
Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial
Lionel Sebbag, Lionel Sebbag, Victoria L. Broadbent, Danielle E. Kenne, Ashtyn L. Perrin, Jonathan P. Mochel   +5 more
doaj   +1 more source

SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation

bioRxiv, 2018
Motivation Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of ...
Justina Jankauskaite, Brian Jiménez-García, J. Dapkūnas, J. Fernández-Recio, I. Moal   +4 more
semanticscholar   +1 more source

Arsenic Binding to Proteins

Chemical Reviews, 2013
Arsenic is a trace element found in the earth’s crust at an average concentration of ∼5 μg/g (ppm). Although its relative abundance in the earth’s crust is about 54th, arsenic can become concentrated in some parts of the world because of natural mineralization. Arsenic is a component of 245 minerals, associated most frequently with other metals such as
Xing-Fang Li, William R. Cullen, X. Chris Le, Shengwen Shen, Michael Weinfeld   +4 more
openaire   +3 more sources

Impact of Protein Binding Capacity and Daily Dosage of a Drug on Total Serum Bilirubin Levels in Susceptible Infants

Children, 2023
Hyperbilirubinemia is a common pathological condition in neonates. Free bilirubin can penetrate the blood–brain barrier (BBB), which can lead to bilirubin neurotoxicity.
Zon-Min Lee, Ling-Sai Chang, Kuang-Che Kuo, Meng-Chiao Lin, Hong-Ren Yu   +4 more
doaj   +1 more source

DeeplyTough: Learning Structural Comparison of Protein Binding Sites

bioRxiv, 2019
Motivation Protein binding site comparison (pocket matching) is of importance in drug discovery. Identification of similar binding sites can help guide efforts for hit finding, understanding polypharmacology and characterization of protein function.
M. Simonovsky, Joshua Meyers
semanticscholar   +1 more source